Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder

Mamoru Yamamoto; Tatsusada Okuno; Jin Lan Piao; Mikito Shimizu; Katsuichi Miyamoto; Takamasa Nukui; Makoto Kinoshita; Toru Koda; Ratna Dini Haryuni; Hideki Mochizuki; Tomoyuki Sugimoto; Yuji Nakatsuji

doi:10.1016/j.jocn.2022.12.005

Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder

Mamoru Yamamoto, Tatsusada Okuno^*, Jin Lan Piao, Mikito Shimizu, Katsuichi Miyamoto, Takamasa Nukui, Makoto Kinoshita, Toru Koda, Ratna Dini Haryuni, Hideki Mochizuki, Tomoyuki Sugimoto, Yuji Nakatsuji

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.

Original language	English
Pages (from-to)	129-132
Number of pages	4
Journal	Journal of Clinical Neuroscience
Volume	107
DOIs	https://doi.org/10.1016/j.jocn.2022.12.005
State	Published - 2023/01

Keywords

CSF
NMOSD
dsDNA

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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Yamamoto, M., Okuno, T., Piao, J. L., Shimizu, M., Miyamoto, K., Nukui, T., Kinoshita, M., Koda, T., Dini Haryuni, R., Mochizuki, H., Sugimoto, T., & Nakatsuji, Y. (2023). Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder. Journal of Clinical Neuroscience, 107, 129-132. https://doi.org/10.1016/j.jocn.2022.12.005

@article{fe8f45c13129457e8a9292e914a4318f,

title = "Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder",

abstract = "Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.",

keywords = "CSF, NMOSD, dsDNA",

author = "Mamoru Yamamoto and Tatsusada Okuno and Piao, {Jin Lan} and Mikito Shimizu and Katsuichi Miyamoto and Takamasa Nukui and Makoto Kinoshita and Toru Koda and {Dini Haryuni}, Ratna and Hideki Mochizuki and Tomoyuki Sugimoto and Yuji Nakatsuji",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2023",

month = jan,

doi = "10.1016/j.jocn.2022.12.005",

language = "英語",

volume = "107",

pages = "129--132",

journal = "Journal of Clinical Neuroscience",

issn = "0967-5868",

publisher = "Churchill Livingstone",

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Yamamoto, M, Okuno, T, Piao, JL, Shimizu, M, Miyamoto, K, Nukui, T, Kinoshita, M, Koda, T, Dini Haryuni, R, Mochizuki, H, Sugimoto, T & Nakatsuji, Y 2023, 'Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder', Journal of Clinical Neuroscience, vol. 107, pp. 129-132. https://doi.org/10.1016/j.jocn.2022.12.005

TY - JOUR

T1 - Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder

AU - Yamamoto, Mamoru

AU - Okuno, Tatsusada

AU - Piao, Jin Lan

AU - Shimizu, Mikito

AU - Miyamoto, Katsuichi

AU - Nukui, Takamasa

AU - Kinoshita, Makoto

AU - Koda, Toru

AU - Dini Haryuni, Ratna

AU - Mochizuki, Hideki

AU - Sugimoto, Tomoyuki

AU - Nakatsuji, Yuji

PY - 2023/1

Y1 - 2023/1

N2 - Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.

AB - Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.

KW - CSF

KW - NMOSD

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U2 - 10.1016/j.jocn.2022.12.005

DO - 10.1016/j.jocn.2022.12.005

M3 - 学術論文

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AN - SCOPUS:85144295410

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JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

ER -

Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder

Abstract

Keywords

ASJC Scopus subject areas

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