Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Ryoya Takakura; Kaho Koyama; Marina Kuwata; Tsuyoshi Yamada; Hironao Sajiki; Yoshinari Sawama

doi:10.1039/d0ob01397h

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Ryoya Takakura, Kaho Koyama, Marina Kuwata, Tsuyoshi Yamada, Hironao Sajiki^*, Yoshinari Sawama^*

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A Knoevenagel condensation of various aldehydes with malononitrile effectively proceeded in the presence of hydroquinone/benzoquinone mixed catalysts at room temperature in H2O. Furthermore, γ-deuterium-labeled α,β-unsaturated nitrile derivatives were also constructed via a deuteration of an aliphatic aldehyde in D2O using a basic resin and the subsequent Knoevenagel condensation.

Original language	English
Pages (from-to)	6594-6597
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	18
Issue number	34
DOIs	https://doi.org/10.1039/d0ob01397h
State	Published - 2020/09/14

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/d0ob01397h

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title = "Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation",

abstract = "A Knoevenagel condensation of various aldehydes with malononitrile effectively proceeded in the presence of hydroquinone/benzoquinone mixed catalysts at room temperature in H2O. Furthermore, γ-deuterium-labeled α,β-unsaturated nitrile derivatives were also constructed via a deuteration of an aliphatic aldehyde in D2O using a basic resin and the subsequent Knoevenagel condensation.",

author = "Ryoya Takakura and Kaho Koyama and Marina Kuwata and Tsuyoshi Yamada and Hironao Sajiki and Yoshinari Sawama",

note = "Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",

year = "2020",

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doi = "10.1039/d0ob01397h",

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T1 - Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

AU - Takakura, Ryoya

AU - Koyama, Kaho

AU - Kuwata, Marina

AU - Yamada, Tsuyoshi

AU - Sajiki, Hironao

AU - Sawama, Yoshinari

PY - 2020/9/14

Y1 - 2020/9/14

N2 - A Knoevenagel condensation of various aldehydes with malononitrile effectively proceeded in the presence of hydroquinone/benzoquinone mixed catalysts at room temperature in H2O. Furthermore, γ-deuterium-labeled α,β-unsaturated nitrile derivatives were also constructed via a deuteration of an aliphatic aldehyde in D2O using a basic resin and the subsequent Knoevenagel condensation.

AB - A Knoevenagel condensation of various aldehydes with malononitrile effectively proceeded in the presence of hydroquinone/benzoquinone mixed catalysts at room temperature in H2O. Furthermore, γ-deuterium-labeled α,β-unsaturated nitrile derivatives were also constructed via a deuteration of an aliphatic aldehyde in D2O using a basic resin and the subsequent Knoevenagel condensation.

UR - http://www.scopus.com/inward/record.url?scp=85090250174&partnerID=8YFLogxK

U2 - 10.1039/d0ob01397h

DO - 10.1039/d0ob01397h

M3 - 学術論文

C2 - 32813006

AN - SCOPUS:85090250174

SN - 1477-0520

VL - 18

SP - 6594

EP - 6597

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 34

ER -

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Abstract

ASJC Scopus subject areas

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