Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Suresh Awale; Ahmed M. Tawila; Dya Fita Dibwe; Jun ya Ueda; Sijia Sun; Sirivan Athikomkulchai; Chandrashaker Balachandran; Ikuo Saiki; Kinzo Matsumoto; Hiroyasu Esumi

doi:10.1016/j.bmcl.2017.03.021

Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Suresh Awale^*, Ahmed M. Tawila, Dya Fita Dibwe, Jun ya Ueda, Sijia Sun, Sirivan Athikomkulchai, Chandrashaker Balachandran, Ikuo Saiki, Kinzo Matsumoto, Hiroyasu Esumi

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC₅₀, 20.1 μM), PSN-1 (PC₅₀, 9.7 μM), MIA PaCa-2 (PC₅₀, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).

Original language	English
Pages (from-to)	1967-1971
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2017.03.021
State	Published - 2017

Keywords

Antiausterity agents
PANC-1
Pancreatic cancer
Preferential cytotoxicity
Uvaria dac

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2017.03.021

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@article{35d4822bded742ea8b2b15dfaab8dbb7,

title = "Highly oxygenated antiausterity agents from the leaves of Uvaria dac",

abstract = "From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).",

keywords = "Antiausterity agents, PANC-1, Pancreatic cancer, Preferential cytotoxicity, Uvaria dac",

author = "Suresh Awale and Tawila, {Ahmed M.} and Dibwe, {Dya Fita} and Ueda, {Jun ya} and Sijia Sun and Sirivan Athikomkulchai and Chandrashaker Balachandran and Ikuo Saiki and Kinzo Matsumoto and Hiroyasu Esumi",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2017.03.021",

language = "英語",

volume = "27",

pages = "1967--1971",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "9",

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TY - JOUR

T1 - Highly oxygenated antiausterity agents from the leaves of Uvaria dac

AU - Awale, Suresh

AU - Tawila, Ahmed M.

AU - Dibwe, Dya Fita

AU - Ueda, Jun ya

AU - Sun, Sijia

AU - Athikomkulchai, Sirivan

AU - Balachandran, Chandrashaker

AU - Saiki, Ikuo

AU - Matsumoto, Kinzo

AU - Esumi, Hiroyasu

PY - 2017

Y1 - 2017

N2 - From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).

AB - From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).

KW - Antiausterity agents

KW - PANC-1

KW - Pancreatic cancer

KW - Preferential cytotoxicity

KW - Uvaria dac

UR - http://www.scopus.com/inward/record.url?scp=85015942234&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2017.03.021

DO - 10.1016/j.bmcl.2017.03.021

M3 - 学術論文

C2 - 28342587

AN - SCOPUS:85015942234

SN - 0960-894X

VL - 27

SP - 1967

EP - 1971

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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