Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Suresh Awale*, Ahmed M. Tawila, Dya Fita Dibwe, Jun ya Ueda, Sijia Sun, Sirivan Athikomkulchai, Chandrashaker Balachandran, Ikuo Saiki, Kinzo Matsumoto, Hiroyasu Esumi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).

Original languageEnglish
Pages (from-to)1967-1971
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number9
DOIs
StatePublished - 2017

Keywords

  • Antiausterity agents
  • PANC-1
  • Pancreatic cancer
  • Preferential cytotoxicity
  • Uvaria dac

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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