High pressure mediated three component Strecker synthesis of α-aminonitriles from ketones, aromatic amines and trimethylsilyl cyanide

Kiyoshi Matsumoto*, Jong Chul Kim, Naoto Hayashi, Gérard Jenner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

High pressure (600 MPa) reaction conditions, in the absence of a catalyst, have proved to be a powerful way to stimulate the three component Strecker reaction synthesis of α-aminonitriles in high yields. Examples of two types of double Strecker reactions were also described.

Original languageEnglish
Pages (from-to)9167-9169
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number50
DOIs
StatePublished - 2002/12/09

Keywords

  • High pressure
  • Strecker reaction
  • Trimethylsilyl cyanide
  • α-aminonitriles

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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