Gender differences in expression of organic cation transporter OCT2 in rat kidney

Yumiko Urakami; Nobuhiko Nakamura; Kazushige Takahashi; Masahiro Okuda; Hideyuki Saito; Yukiya Hashimoto; Ken Ichi Inui

doi:10.1016/S0014-5793(99)01491-X

Gender differences in expression of organic cation transporter OCT2 in rat kidney

Yumiko Urakami, Nobuhiko Nakamura, Kazushige Takahashi, Masahiro Okuda, Hideyuki Saito, Yukiya Hashimoto, Ken Ichi Inui

Clinical Pharmacokinetics

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membrane vesicles of male rat kidney showed a higher transport activity for tetraethylammonium than those of female rat kidney. The expression levels of rOCT2 mRNA and protein in the kidney of males were much higher than those in females. There was no gender difference in mRNA expression of rOCT1 and rOCT3. These findings suggest that rOCT2 is responsible for the gender differences in renal basolateral membrane organic cation transport activity. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	339-342
Number of pages	4
Journal	FEBS Letters
Volume	461
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)01491-X
State	Published - 1999/11/19

Keywords

Basolateral membrane
Organic cation transporter
Rat kidney
Renal tubular secretion
Tetraethylammonium

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(99)01491-X

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title = "Gender differences in expression of organic cation transporter OCT2 in rat kidney",

abstract = "The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membrane vesicles of male rat kidney showed a higher transport activity for tetraethylammonium than those of female rat kidney. The expression levels of rOCT2 mRNA and protein in the kidney of males were much higher than those in females. There was no gender difference in mRNA expression of rOCT1 and rOCT3. These findings suggest that rOCT2 is responsible for the gender differences in renal basolateral membrane organic cation transport activity. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "Basolateral membrane, Organic cation transporter, Rat kidney, Renal tubular secretion, Tetraethylammonium",

author = "Yumiko Urakami and Nobuhiko Nakamura and Kazushige Takahashi and Masahiro Okuda and Hideyuki Saito and Yukiya Hashimoto and Inui, {Ken Ichi}",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Science, Sports, and Culture of Japan, and by a Grant-in-Aid from the Uehara Memorial Foundation.",

year = "1999",

month = nov,

day = "19",

doi = "10.1016/S0014-5793(99)01491-X",

language = "英語",

volume = "461",

pages = "339--342",

journal = "FEBS Letters",

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TY - JOUR

T1 - Gender differences in expression of organic cation transporter OCT2 in rat kidney

AU - Urakami, Yumiko

AU - Nakamura, Nobuhiko

AU - Takahashi, Kazushige

AU - Okuda, Masahiro

AU - Saito, Hideyuki

AU - Hashimoto, Yukiya

AU - Inui, Ken Ichi

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Science, Sports, and Culture of Japan, and by a Grant-in-Aid from the Uehara Memorial Foundation.

PY - 1999/11/19

Y1 - 1999/11/19

N2 - The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membrane vesicles of male rat kidney showed a higher transport activity for tetraethylammonium than those of female rat kidney. The expression levels of rOCT2 mRNA and protein in the kidney of males were much higher than those in females. There was no gender difference in mRNA expression of rOCT1 and rOCT3. These findings suggest that rOCT2 is responsible for the gender differences in renal basolateral membrane organic cation transport activity. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membrane vesicles of male rat kidney showed a higher transport activity for tetraethylammonium than those of female rat kidney. The expression levels of rOCT2 mRNA and protein in the kidney of males were much higher than those in females. There was no gender difference in mRNA expression of rOCT1 and rOCT3. These findings suggest that rOCT2 is responsible for the gender differences in renal basolateral membrane organic cation transport activity. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - Basolateral membrane

KW - Organic cation transporter

KW - Rat kidney

KW - Renal tubular secretion

KW - Tetraethylammonium

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U2 - 10.1016/S0014-5793(99)01491-X

DO - 10.1016/S0014-5793(99)01491-X

M3 - 学術論文

C2 - 10567723

AN - SCOPUS:0032717266

SN - 0014-5793

VL - 461

SP - 339

EP - 342

JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

Gender differences in expression of organic cation transporter OCT2 in rat kidney

Abstract

Keywords

ASJC Scopus subject areas

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