Garbled messages and corrupted translations

Tilman Schneider-Poetsch*, Takeo Usui, Daisuke Kaida, Minoru Yoshida

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Following transcription, genomic information begins a long journey toward translation of its nucleotide sequence into the amino acids of a protein. In eukaryotes, synthesized pre-mRNAs become processed to mature mRNAs by 5′-end capping, splicing, 3′-end cleavage and polyadenylation in the nucleus, before being scrutinized for premature stop codons. Each step requires high precision and control to ensure that an intact and readable message is exported to the cytoplasm before finally becoming translated. Two important aspects of these processes are accurately managed by ribonucleoprotein machineriesthe spliceosome and the ribosome. Recently, several natural products targeting these macromolecular assemblies have been reported. For the first time in eukaryotes, these molecules allow chemical disruption and dissection of the sophisticated machinery that regulates post-transcriptional events. Beyond their great potential as bioprobes for investigating mRNA regulation and protein synthesis, these compounds also show promise in opening new therapeutic approaches.

Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalNature Chemical Biology
Volume6
Issue number3
DOIs
StatePublished - 2010/03

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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