TY - JOUR
T1 - Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor
AU - Bridge, Julia A.
AU - Kanamori, Masahiko
AU - Ma, Zhigui
AU - Pickering, Diane
AU - Hill, D. Ashley
AU - Lydiatt, William
AU - Lui, Man Yee
AU - Colleoni, Gisele W.B.
AU - Antonescu, Cristina R.
AU - Ladanyi, Marc
AU - Morris, Stephan W.
N1 - Funding Information:
Supported by National Cancer Institute grants NCI-P30 CA36727 , the John A. Wiebe Jr. Children's Health Care Fund and National Childhood Cancer Foundation (to J. A. B.), National Cancer Institute grant NCI CA69129 and CORE grant CA21765 (to S. W. M.), the American Lebanese Syrian Associated Charities, the St. Jude Children's Hospital (to S. W. M.), and the Fundaçao de Amparo à Pesquisa do Estado de Sao Paulo (to G. W. B. C.).
PY - 2001
Y1 - 2001
N2 - Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46, XX, t(2;17)(p23;q23), add(16)(q24)].
AB - Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46, XX, t(2;17)(p23;q23), add(16)(q24)].
UR - http://www.scopus.com/inward/record.url?scp=0034879895&partnerID=8YFLogxK
U2 - 10.1016/S0002-9440(10)61711-7
DO - 10.1016/S0002-9440(10)61711-7
M3 - 学術論文
C2 - 11485898
AN - SCOPUS:0034879895
SN - 0002-9440
VL - 159
SP - 411
EP - 415
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 2
ER -