Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

Shigeru Saito; Naoya Harada; Naoto Ishii; Takeshi Morii; Shigeyoshi Sakakura; Masahiro Enomoto; Hideshi Umekage; Kiyoshi Nishikawa; Nobuhiro Narita; Masataka Nakamura; Kazuo Sugamura; Hajime Morikawa

doi:10.1006/bbrc.1997.6121

Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

Shigeru Saito^*, Naoya Harada, Naoto Ishii, Takeshi Morii, Shigeyoshi Sakakura, Masahiro Enomoto, Hideshi Umekage, Kiyoshi Nishikawa, Nobuhiro Narita, Masataka Nakamura, Kazuo Sugamura, Hajime Morikawa

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Abstract

The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.

Original language	English
Pages (from-to)	429-434
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	231
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1997.6121
State	Published - 1997/02/13

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Saito, S., Harada, N., Ishii, N., Morii, T., Sakakura, S., Enomoto, M., Umekage, H., Nishikawa, K., Narita, N., Nakamura, M., Sugamura, K., & Morikawa, H. (1997). Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain. Biochemical and Biophysical Research Communications, 231(2), 429-434. https://doi.org/10.1006/bbrc.1997.6121

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abstract = "The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.",

author = "Shigeru Saito and Naoya Harada and Naoto Ishii and Takeshi Morii and Shigeyoshi Sakakura and Masahiro Enomoto and Hideshi Umekage and Kiyoshi Nishikawa and Nobuhiro Narita and Masataka Nakamura and Kazuo Sugamura and Hajime Morikawa",

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Saito, S, Harada, N, Ishii, N, Morii, T, Sakakura, S, Enomoto, M, Umekage, H, Nishikawa, K, Narita, N, Nakamura, M, Sugamura, K & Morikawa, H 1997, 'Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain', Biochemical and Biophysical Research Communications, vol. 231, no. 2, pp. 429-434. https://doi.org/10.1006/bbrc.1997.6121

TY - JOUR

T1 - Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

AU - Saito, Shigeru

AU - Harada, Naoya

AU - Ishii, Naoto

AU - Morii, Takeshi

AU - Sakakura, Shigeyoshi

AU - Enomoto, Masahiro

AU - Umekage, Hideshi

AU - Nishikawa, Kiyoshi

AU - Narita, Nobuhiro

AU - Nakamura, Masataka

AU - Sugamura, Kazuo

AU - Morikawa, Hajime

PY - 1997/2/13

Y1 - 1997/2/13

N2 - The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.

AB - The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.

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JF - Biochemical and Biophysical Research Communications

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Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

Abstract

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