Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease

Jun Ichiro Nishi; Kimiyoshi Arimura; Atae Utsunomiya; Suguru Yonezawa; Kiyoshi Kawakami; Nobuaki Maeno; Osamu Ijichi; Naoaki Ikarimoto; Masanori Nakata; Isao Kitajima; Takahiko Fukushige; Hideo Takamatsu; Koichiro Miyata; Ikuro Maruyama

doi:10.1046/j.1365-2141.1999.01208.x

Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease

Jun Ichiro Nishi^*, Kimiyoshi Arimura, Atae Utsunomiya, Suguru Yonezawa, Kiyoshi Kawakami, Nobuaki Maeno, Osamu Ijichi, Naoaki Ikarimoto, Masanori Nakata, Isao Kitajima, Takahiko Fukushige, Hideo Takamatsu, Koichiro Miyata, Ikuro Maruyama

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Abstract

To evaluate the possible involvement of vascular endothelial growth factor (VEGF) in the pathogenesis of Castleman's disease, we studied VEGF levels in sera and supernatants of cultured lymph nodes from two patients with the plasma cell type of Castleman's disease, and analysed the expression of VEGF immunohistochemically in the lymph nodes. Clinically, one patient was classified as the localized type and the other as the multicentric type. Histologically, mature plasma cells and hyalinized vessels were prominent in the interfollicular region. The VEGF levels of the sera and the supernatants of cultured lymph nodes of both patients were higher than those of normal controls. VEGF was strongly expressed in plasma cells in the interfollicular region of the lymph nodes of both patients, but rarely in normal lymph nodes. Our results suggest that VEGF may be involved in the marked vascular proliferation in the interfollicular region of the lymph nodes of he plasma cell type of Castleman's disease.

Original language	English
Pages (from-to)	482-485
Number of pages	4
Journal	British Journal of Haematology
Volume	104
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.1999.01208.x
State	Published - 1999

Keywords

Castleman's disease
Lymph node
Plasma cell type
Vascular endothelial growth factor
Vascular proliferation

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.1999.01208.x

Cite this

Nishi, J. I., Arimura, K., Utsunomiya, A., Yonezawa, S., Kawakami, K., Maeno, N., Ijichi, O., Ikarimoto, N., Nakata, M., Kitajima, I., Fukushige, T., Takamatsu, H., Miyata, K., & Maruyama, I. (1999). Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease. British Journal of Haematology, 104(3), 482-485. https://doi.org/10.1046/j.1365-2141.1999.01208.x

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title = "Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease",

abstract = "To evaluate the possible involvement of vascular endothelial growth factor (VEGF) in the pathogenesis of Castleman's disease, we studied VEGF levels in sera and supernatants of cultured lymph nodes from two patients with the plasma cell type of Castleman's disease, and analysed the expression of VEGF immunohistochemically in the lymph nodes. Clinically, one patient was classified as the localized type and the other as the multicentric type. Histologically, mature plasma cells and hyalinized vessels were prominent in the interfollicular region. The VEGF levels of the sera and the supernatants of cultured lymph nodes of both patients were higher than those of normal controls. VEGF was strongly expressed in plasma cells in the interfollicular region of the lymph nodes of both patients, but rarely in normal lymph nodes. Our results suggest that VEGF may be involved in the marked vascular proliferation in the interfollicular region of the lymph nodes of he plasma cell type of Castleman's disease.",

keywords = "Castleman's disease, Lymph node, Plasma cell type, Vascular endothelial growth factor, Vascular proliferation",

author = "Nishi, {Jun Ichiro} and Kimiyoshi Arimura and Atae Utsunomiya and Suguru Yonezawa and Kiyoshi Kawakami and Nobuaki Maeno and Osamu Ijichi and Naoaki Ikarimoto and Masanori Nakata and Isao Kitajima and Takahiko Fukushige and Hideo Takamatsu and Koichiro Miyata and Ikuro Maruyama",

year = "1999",

doi = "10.1046/j.1365-2141.1999.01208.x",

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Nishi, JI, Arimura, K, Utsunomiya, A, Yonezawa, S, Kawakami, K, Maeno, N, Ijichi, O, Ikarimoto, N, Nakata, M, Kitajima, I, Fukushige, T, Takamatsu, H, Miyata, K & Maruyama, I 1999, 'Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease', British Journal of Haematology, vol. 104, no. 3, pp. 482-485. https://doi.org/10.1046/j.1365-2141.1999.01208.x

TY - JOUR

T1 - Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease

AU - Nishi, Jun Ichiro

AU - Arimura, Kimiyoshi

AU - Utsunomiya, Atae

AU - Yonezawa, Suguru

AU - Kawakami, Kiyoshi

AU - Maeno, Nobuaki

AU - Ijichi, Osamu

AU - Ikarimoto, Naoaki

AU - Nakata, Masanori

AU - Kitajima, Isao

AU - Fukushige, Takahiko

AU - Takamatsu, Hideo

AU - Miyata, Koichiro

AU - Maruyama, Ikuro

PY - 1999

Y1 - 1999

N2 - To evaluate the possible involvement of vascular endothelial growth factor (VEGF) in the pathogenesis of Castleman's disease, we studied VEGF levels in sera and supernatants of cultured lymph nodes from two patients with the plasma cell type of Castleman's disease, and analysed the expression of VEGF immunohistochemically in the lymph nodes. Clinically, one patient was classified as the localized type and the other as the multicentric type. Histologically, mature plasma cells and hyalinized vessels were prominent in the interfollicular region. The VEGF levels of the sera and the supernatants of cultured lymph nodes of both patients were higher than those of normal controls. VEGF was strongly expressed in plasma cells in the interfollicular region of the lymph nodes of both patients, but rarely in normal lymph nodes. Our results suggest that VEGF may be involved in the marked vascular proliferation in the interfollicular region of the lymph nodes of he plasma cell type of Castleman's disease.

AB - To evaluate the possible involvement of vascular endothelial growth factor (VEGF) in the pathogenesis of Castleman's disease, we studied VEGF levels in sera and supernatants of cultured lymph nodes from two patients with the plasma cell type of Castleman's disease, and analysed the expression of VEGF immunohistochemically in the lymph nodes. Clinically, one patient was classified as the localized type and the other as the multicentric type. Histologically, mature plasma cells and hyalinized vessels were prominent in the interfollicular region. The VEGF levels of the sera and the supernatants of cultured lymph nodes of both patients were higher than those of normal controls. VEGF was strongly expressed in plasma cells in the interfollicular region of the lymph nodes of both patients, but rarely in normal lymph nodes. Our results suggest that VEGF may be involved in the marked vascular proliferation in the interfollicular region of the lymph nodes of he plasma cell type of Castleman's disease.

KW - Castleman's disease

KW - Lymph node

KW - Plasma cell type

KW - Vascular endothelial growth factor

KW - Vascular proliferation

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AN - SCOPUS:0033061386

SN - 0007-1048

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IS - 3

ER -

Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease

Abstract

Keywords

ASJC Scopus subject areas

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