TY - JOUR
T1 - Evaluation of the toxicity of tetrabromobisphenol A and some of its oxidation products using a micro-scale algal growth inhibition test
AU - Sazawa, Kazuto
AU - Furuhashi, Yoshiki
AU - Hata, Noriko
AU - Taguchi, Shigeru
AU - Fukushima, Masami
AU - Kuramitz, Hideki
N1 - Funding Information:
This research was supported by Grants-in-Aid for scientific Research from the Japan Society for the Promotion of Science (No. 21310048).
PY - 2013/3
Y1 - 2013/3
N2 - A micro-scale algal growth inhibition (μ-AGI) test using a common micro-plate based fluorometric detection was used to demonstrate the effects of humic substances (HSs) on the toxicity of tetrabromobisphenol A (TBBPA) and its oxidative decomposition products 2,5-dibromo-1,4-benzoquinone (2,5-DBBQ), 2,5-dibromohydroquinone (2,5-DBHQ), 2,6-dibromobenzoquinone (2,6-DBBQ), and 2,6-dibromophenol (2,6-DBP) to Pseudokirchneriella subcapitata. The EC50 values were: EC50(TBBPA) = 7 mg L-1, EC50(2,5-DBHQ) = 7 mg L-1, EC50(2,5-DBBQ) = 19 mg L-1, EC50(2,6-DBP) = 49 mg L-1, and EC50(2,6-DBBQ) = 13 mg L-1. The toxicity of the chemicals was slightly lower in the presence of HA. The toxicity of TBBPA decomposed by a biomimetic catalytic system consisting of iron (III) 5,10,15,20-tetrakis (p-sulfonatophenyl) porphyrin (Fe(III)-TPPS) and KHSO5 was also evaluated using P. subcapitata and Chlamydomonas reinhardtii.
AB - A micro-scale algal growth inhibition (μ-AGI) test using a common micro-plate based fluorometric detection was used to demonstrate the effects of humic substances (HSs) on the toxicity of tetrabromobisphenol A (TBBPA) and its oxidative decomposition products 2,5-dibromo-1,4-benzoquinone (2,5-DBBQ), 2,5-dibromohydroquinone (2,5-DBHQ), 2,6-dibromobenzoquinone (2,6-DBBQ), and 2,6-dibromophenol (2,6-DBP) to Pseudokirchneriella subcapitata. The EC50 values were: EC50(TBBPA) = 7 mg L-1, EC50(2,5-DBHQ) = 7 mg L-1, EC50(2,5-DBBQ) = 19 mg L-1, EC50(2,6-DBP) = 49 mg L-1, and EC50(2,6-DBBQ) = 13 mg L-1. The toxicity of the chemicals was slightly lower in the presence of HA. The toxicity of TBBPA decomposed by a biomimetic catalytic system consisting of iron (III) 5,10,15,20-tetrakis (p-sulfonatophenyl) porphyrin (Fe(III)-TPPS) and KHSO5 was also evaluated using P. subcapitata and Chlamydomonas reinhardtii.
KW - Pseudokirchneriella subcapitata
KW - algal growth inhibition test
KW - humic acid
KW - tetrabromobisphenol A
UR - http://www.scopus.com/inward/record.url?scp=84877828051&partnerID=8YFLogxK
U2 - 10.1080/02772248.2013.775290
DO - 10.1080/02772248.2013.775290
M3 - 学術論文
AN - SCOPUS:84877828051
SN - 0277-2248
VL - 95
SP - 472
EP - 482
JO - Toxicological and Environmental Chemistry
JF - Toxicological and Environmental Chemistry
IS - 3
ER -