Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy

Yasumitsu Ishimaru; Yusuke Oshima; Yuuki Imai; Tadahiro Iimura; Sota Takanezawa; Kazunori Hino; Hiromasa Miura

doi:10.1117/12.2274980

Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy

Yasumitsu Ishimaru, Yusuke Oshima, Yuuki Imai, Tadahiro Iimura, Sota Takanezawa, Kazunori Hino, Hiromasa Miura

Intellectual Information Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

To evaluate the bone quality in the osteoporosis, we generated sciatic nerve resection (NX) mice as an osteoporosis model and analyzed by Raman spectroscopy. Raman spectra were measured in anterior cortical surface of the proximal tibia at 5 points in each bone. After that, the samples were fixed with 70% ethanol. We then performed DXA and μCT measurement. Raman peak intensity ratios were significantly different between NX and Control. Those changes in the Raman peak intensity ratios may reflect loss of bone quality in the osteoporosis model. Raman spectroscopy is a promising technique for measuring the bone quality and bone strength.

Original language	English
Title of host publication	Biomedical Imaging and Sensing Conference
Editors	Yasuhiro Awatsuji, Osamu Matoba, Yoshihisa Aizu, Toyohiko Yatagai
Publisher	SPIE
ISBN (Electronic)	9781510610033
DOIs	https://doi.org/10.1117/12.2274980
State	Published - 2017
Event	3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan Duration: 2017/04/19 → 2017/04/21

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10251
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	3rd Biomedical Imaging and Sensing Conference
Country/Territory	Japan
City	Yokohama
Period	2017/04/19 → 2017/04/21

Keywords

Bone Quality
Collagen
Osteoporosis
Raman Spectroscopy
Sciatic Nerve Resection Mice

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.2274980

Cite this

Ishimaru, Y., Oshima, Y., Imai, Y., Iimura, T., Takanezawa, S., Hino, K., & Miura, H. (2017). Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy. In Y. Awatsuji, O. Matoba, Y. Aizu, & T. Yatagai (Eds.), Biomedical Imaging and Sensing Conference Article 102511D (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10251). SPIE. https://doi.org/10.1117/12.2274980

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title = "Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy",

abstract = "To evaluate the bone quality in the osteoporosis, we generated sciatic nerve resection (NX) mice as an osteoporosis model and analyzed by Raman spectroscopy. Raman spectra were measured in anterior cortical surface of the proximal tibia at 5 points in each bone. After that, the samples were fixed with 70% ethanol. We then performed DXA and μCT measurement. Raman peak intensity ratios were significantly different between NX and Control. Those changes in the Raman peak intensity ratios may reflect loss of bone quality in the osteoporosis model. Raman spectroscopy is a promising technique for measuring the bone quality and bone strength.",

keywords = "Bone Quality, Collagen, Osteoporosis, Raman Spectroscopy, Sciatic Nerve Resection Mice",

author = "Yasumitsu Ishimaru and Yusuke Oshima and Yuuki Imai and Tadahiro Iimura and Sota Takanezawa and Kazunori Hino and Hiromasa Miura",

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year = "2017",

doi = "10.1117/12.2274980",

language = "英語",

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Ishimaru, Y, Oshima, Y, Imai, Y, Iimura, T, Takanezawa, S, Hino, K & Miura, H 2017, Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy. in Y Awatsuji, O Matoba, Y Aizu & T Yatagai (eds), Biomedical Imaging and Sensing Conference., 102511D, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10251, SPIE, 3rd Biomedical Imaging and Sensing Conference, Yokohama, Japan, 2017/04/19. https://doi.org/10.1117/12.2274980

Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy. / Ishimaru, Yasumitsu; Oshima, Yusuke; Imai, Yuuki et al.
Biomedical Imaging and Sensing Conference. ed. / Yasuhiro Awatsuji; Osamu Matoba; Yoshihisa Aizu; Toyohiko Yatagai. SPIE, 2017. 102511D (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10251).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ishimaru, Yasumitsu

AU - Oshima, Yusuke

AU - Imai, Yuuki

AU - Iimura, Tadahiro

AU - Takanezawa, Sota

AU - Hino, Kazunori

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N2 - To evaluate the bone quality in the osteoporosis, we generated sciatic nerve resection (NX) mice as an osteoporosis model and analyzed by Raman spectroscopy. Raman spectra were measured in anterior cortical surface of the proximal tibia at 5 points in each bone. After that, the samples were fixed with 70% ethanol. We then performed DXA and μCT measurement. Raman peak intensity ratios were significantly different between NX and Control. Those changes in the Raman peak intensity ratios may reflect loss of bone quality in the osteoporosis model. Raman spectroscopy is a promising technique for measuring the bone quality and bone strength.

AB - To evaluate the bone quality in the osteoporosis, we generated sciatic nerve resection (NX) mice as an osteoporosis model and analyzed by Raman spectroscopy. Raman spectra were measured in anterior cortical surface of the proximal tibia at 5 points in each bone. After that, the samples were fixed with 70% ethanol. We then performed DXA and μCT measurement. Raman peak intensity ratios were significantly different between NX and Control. Those changes in the Raman peak intensity ratios may reflect loss of bone quality in the osteoporosis model. Raman spectroscopy is a promising technique for measuring the bone quality and bone strength.

KW - Bone Quality

KW - Collagen

KW - Osteoporosis

KW - Raman Spectroscopy

KW - Sciatic Nerve Resection Mice

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M3 - 会議への寄与

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T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Biomedical Imaging and Sensing Conference

A2 - Awatsuji, Yasuhiro

A2 - Matoba, Osamu

A2 - Aizu, Yoshihisa

A2 - Yatagai, Toyohiko

PB - SPIE

T2 - 3rd Biomedical Imaging and Sensing Conference

Y2 - 19 April 2017 through 21 April 2017

ER -

Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy

Abstract

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Conference

Keywords

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