Evaluation of an edible blue-green alga, aphanothece sacrum, for its inhibitory effect on replication of herpes simplex virus type 2 and influenza virus type A

Fumie Ogura; Kyoko Hayashi; Jung Bum Lee; Kenji Kanekiyo; Toshimitsu Hayashi

doi:10.1271/bbb.100336

Evaluation of an edible blue-green alga, aphanothece sacrum, for its inhibitory effect on replication of herpes simplex virus type 2 and influenza virus type A

Fumie Ogura, Kyoko Hayashi, Jung Bum Lee, Kenji Kanekiyo, Toshimitsu Hayashi^*

^*Corresponding author for this work

Plant Resource Sciences

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A hot-water extract of Aphanothece sacrum, an edibleb aquacultured blue-green alga, was found to show a remarkable inhibitory effect on the replication of enveloped viruses including herpes simplex virus type 2 (HSV-2) and influenza virus type A (IFV-A,H1N1) in vitro. The main active components were suggested to be sulfated polysaccharides in non-dialyzable portion (ASWPH). ASWPH was found to inhibit the viral adsorption to the receptor of the host cells involved in the replication process of HSV-2 and IFV-A. In addition, while the penetration stage of HSV-2 was also significantly suppressed with ASWPH, no such effect was observed in the replication of IFV-A. These results suggest that ASWPH might be useful in the prevention of infectious diseases caused by HSV-2 as well as IFV-A.

Original language	English
Pages (from-to)	1687-1690
Number of pages	4
Journal	Bioscience, biotechnology, and biochemistry
Volume	74
Issue number	8
DOIs	https://doi.org/10.1271/bbb.100336
State	Published - 2010

Keywords

Antiviral effect
Aphanothece sacrum
Herpes simplex virus type 2 (HSV-2)
Influenza virus type A (IFV-A)
Sulfated polysaccharide

ASJC Scopus subject areas

General Medicine

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10.1271/bbb.100336

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title = "Evaluation of an edible blue-green alga, aphanothece sacrum, for its inhibitory effect on replication of herpes simplex virus type 2 and influenza virus type A",

abstract = "A hot-water extract of Aphanothece sacrum, an edibleb aquacultured blue-green alga, was found to show a remarkable inhibitory effect on the replication of enveloped viruses including herpes simplex virus type 2 (HSV-2) and influenza virus type A (IFV-A,H1N1) in vitro. The main active components were suggested to be sulfated polysaccharides in non-dialyzable portion (ASWPH). ASWPH was found to inhibit the viral adsorption to the receptor of the host cells involved in the replication process of HSV-2 and IFV-A. In addition, while the penetration stage of HSV-2 was also significantly suppressed with ASWPH, no such effect was observed in the replication of IFV-A. These results suggest that ASWPH might be useful in the prevention of infectious diseases caused by HSV-2 as well as IFV-A.",

keywords = "Antiviral effect, Aphanothece sacrum, Herpes simplex virus type 2 (HSV-2), Influenza virus type A (IFV-A), Sulfated polysaccharide",

author = "Fumie Ogura and Kyoko Hayashi and Lee, {Jung Bum} and Kenji Kanekiyo and Toshimitsu Hayashi",

year = "2010",

doi = "10.1271/bbb.100336",

language = "英語",

volume = "74",

pages = "1687--1690",

journal = "Bioscience, biotechnology, and biochemistry",

issn = "0916-8451",

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T1 - Evaluation of an edible blue-green alga, aphanothece sacrum, for its inhibitory effect on replication of herpes simplex virus type 2 and influenza virus type A

AU - Ogura, Fumie

AU - Hayashi, Kyoko

AU - Lee, Jung Bum

AU - Kanekiyo, Kenji

AU - Hayashi, Toshimitsu

PY - 2010

Y1 - 2010

N2 - A hot-water extract of Aphanothece sacrum, an edibleb aquacultured blue-green alga, was found to show a remarkable inhibitory effect on the replication of enveloped viruses including herpes simplex virus type 2 (HSV-2) and influenza virus type A (IFV-A,H1N1) in vitro. The main active components were suggested to be sulfated polysaccharides in non-dialyzable portion (ASWPH). ASWPH was found to inhibit the viral adsorption to the receptor of the host cells involved in the replication process of HSV-2 and IFV-A. In addition, while the penetration stage of HSV-2 was also significantly suppressed with ASWPH, no such effect was observed in the replication of IFV-A. These results suggest that ASWPH might be useful in the prevention of infectious diseases caused by HSV-2 as well as IFV-A.

AB - A hot-water extract of Aphanothece sacrum, an edibleb aquacultured blue-green alga, was found to show a remarkable inhibitory effect on the replication of enveloped viruses including herpes simplex virus type 2 (HSV-2) and influenza virus type A (IFV-A,H1N1) in vitro. The main active components were suggested to be sulfated polysaccharides in non-dialyzable portion (ASWPH). ASWPH was found to inhibit the viral adsorption to the receptor of the host cells involved in the replication process of HSV-2 and IFV-A. In addition, while the penetration stage of HSV-2 was also significantly suppressed with ASWPH, no such effect was observed in the replication of IFV-A. These results suggest that ASWPH might be useful in the prevention of infectious diseases caused by HSV-2 as well as IFV-A.

KW - Antiviral effect

KW - Aphanothece sacrum

KW - Herpes simplex virus type 2 (HSV-2)

KW - Influenza virus type A (IFV-A)

KW - Sulfated polysaccharide

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U2 - 10.1271/bbb.100336

DO - 10.1271/bbb.100336

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AN - SCOPUS:77956027834

SN - 0916-8451

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SP - 1687

EP - 1690

JO - Bioscience, biotechnology, and biochemistry

JF - Bioscience, biotechnology, and biochemistry

IS - 8

ER -

Evaluation of an edible blue-green alga, aphanothece sacrum, for its inhibitory effect on replication of herpes simplex virus type 2 and influenza virus type A

Abstract

Keywords

ASJC Scopus subject areas

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