Enhancement of hyperthermia-induced apoptosis by non-thermal effects of ultrasound

Loreto B. Feril; Takashi Kondo; Qing Li Zhao; Ryohei Ogawa

doi:10.1016/S0304-3835(01)00826-6

Enhancement of hyperthermia-induced apoptosis by non-thermal effects of ultrasound

Loreto B. Feril, Takashi Kondo^*, Qing Li Zhao, Ryohei Ogawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

To determine the effect of ultrasound on hyperthermia-induced apoptosis, we exposed U937 cells (in air-saturated suspension) to continuous 1 MHz ultrasound at intensities 0.5 or 1.0 W/cm², considered non-thermal and sub-threshold for inertial cavitation, while at 44.0°C for 10 min. We found that 0.5 W/cm², in combination with hyperthermia, synergistically induced apoptosis. On the other hand, 1.0 W/cm² in combination with hyperthermia showed an augmented instant cell lysis but no significant change in the ratio of apoptosis. This result might be useful when apoptosis induction is desired over instant cell killing in cancer therapy.

Original language	English
Pages (from-to)	63-70
Number of pages	8
Journal	Cancer Letters
Volume	178
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(01)00826-6
State	Published - 2002/04/08

Keywords

Apoptosis
Cancer therapy
Hyperthermia
Ultrasound

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(01)00826-6

Cite this

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title = "Enhancement of hyperthermia-induced apoptosis by non-thermal effects of ultrasound",

abstract = "To determine the effect of ultrasound on hyperthermia-induced apoptosis, we exposed U937 cells (in air-saturated suspension) to continuous 1 MHz ultrasound at intensities 0.5 or 1.0 W/cm2, considered non-thermal and sub-threshold for inertial cavitation, while at 44.0°C for 10 min. We found that 0.5 W/cm2, in combination with hyperthermia, synergistically induced apoptosis. On the other hand, 1.0 W/cm2 in combination with hyperthermia showed an augmented instant cell lysis but no significant change in the ratio of apoptosis. This result might be useful when apoptosis induction is desired over instant cell killing in cancer therapy.",

keywords = "Apoptosis, Cancer therapy, Hyperthermia, Ultrasound",

author = "Feril, {Loreto B.} and Takashi Kondo and Zhao, {Qing Li} and Ryohei Ogawa",

note = "Funding Information: This study was supported in part by the Grant in Aid for Scientific Research on Priority Areas (C) (12217049) from the Ministry of Education, Science, Sports and Culture, Japan. We also wish to acknowledge helpful discussions with Dr P. Riesz, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, MD, USA.",

year = "2002",

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doi = "10.1016/S0304-3835(01)00826-6",

language = "英語",

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TY - JOUR

T1 - Enhancement of hyperthermia-induced apoptosis by non-thermal effects of ultrasound

AU - Feril, Loreto B.

AU - Kondo, Takashi

AU - Zhao, Qing Li

AU - Ogawa, Ryohei

N1 - Funding Information: This study was supported in part by the Grant in Aid for Scientific Research on Priority Areas (C) (12217049) from the Ministry of Education, Science, Sports and Culture, Japan. We also wish to acknowledge helpful discussions with Dr P. Riesz, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, MD, USA.

PY - 2002/4/8

Y1 - 2002/4/8

N2 - To determine the effect of ultrasound on hyperthermia-induced apoptosis, we exposed U937 cells (in air-saturated suspension) to continuous 1 MHz ultrasound at intensities 0.5 or 1.0 W/cm2, considered non-thermal and sub-threshold for inertial cavitation, while at 44.0°C for 10 min. We found that 0.5 W/cm2, in combination with hyperthermia, synergistically induced apoptosis. On the other hand, 1.0 W/cm2 in combination with hyperthermia showed an augmented instant cell lysis but no significant change in the ratio of apoptosis. This result might be useful when apoptosis induction is desired over instant cell killing in cancer therapy.

AB - To determine the effect of ultrasound on hyperthermia-induced apoptosis, we exposed U937 cells (in air-saturated suspension) to continuous 1 MHz ultrasound at intensities 0.5 or 1.0 W/cm2, considered non-thermal and sub-threshold for inertial cavitation, while at 44.0°C for 10 min. We found that 0.5 W/cm2, in combination with hyperthermia, synergistically induced apoptosis. On the other hand, 1.0 W/cm2 in combination with hyperthermia showed an augmented instant cell lysis but no significant change in the ratio of apoptosis. This result might be useful when apoptosis induction is desired over instant cell killing in cancer therapy.

KW - Apoptosis

KW - Cancer therapy

KW - Hyperthermia

KW - Ultrasound

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U2 - 10.1016/S0304-3835(01)00826-6

DO - 10.1016/S0304-3835(01)00826-6

M3 - 学術論文

C2 - 11849742

AN - SCOPUS:0037041267

SN - 0304-3835

VL - 178

SP - 63

EP - 70

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Enhancement of hyperthermia-induced apoptosis by non-thermal effects of ultrasound

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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