Endothelium-dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta

Hirozo Goto; Nobumitsu Tanaka; Kiyoaki Tanigawa; Yutaka Shimada; Takashi Itoh; Katsutoshi Terasawa

doi:10.1002/(SICI)1099-1573(199709)11:6<457::AID-PTR123>3.0.CO;2-J

Endothelium-dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta

Hirozo Goto^*, Nobumitsu Tanaka, Kiyoaki Tanigawa, Yutaka Shimada, Takashi Itoh, Katsutoshi Terasawa

^*Corresponding author for this work

Japanese Oriental Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Arecae semen extract relaxed aortic ring preparations of isolated rat aorta that contained endothelium from 3x10^-7 g/mL, reaching a maximum of 86% at 10^-5 g/mL. Its relaxation did not occur in specimens without endothelium, and was inhibited by pretreatment with 10^-4 M N(G)-nitro-1-arginine methylester. One of the active components was arecoline which is a muscarinic receptor agonist. Another active component was condensed tannin contained in Arecae semen.

Original language	English
Pages (from-to)	457-459
Number of pages	3
Journal	Phytotherapy Research
Volume	11
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1099-1573(199709)11:6<457::AID-PTR123>3.0.CO;2-J
State	Published - 1997/09

Keywords

Arecae semen
Arecoline
Endothelium-dependent relaxing factor
Nitric oxide
Rat aorta
Tannin

ASJC Scopus subject areas

Pharmacology

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10.1002/(SICI)1099-1573(199709)11:6<457::AID-PTR123>3.0.CO;2-J

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title = "Endothelium-dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta",

abstract = "Arecae semen extract relaxed aortic ring preparations of isolated rat aorta that contained endothelium from 3x10-7 g/mL, reaching a maximum of 86% at 10-5 g/mL. Its relaxation did not occur in specimens without endothelium, and was inhibited by pretreatment with 10-4 M N(G)-nitro-1-arginine methylester. One of the active components was arecoline which is a muscarinic receptor agonist. Another active component was condensed tannin contained in Arecae semen.",

keywords = "Arecae semen, Arecoline, Endothelium-dependent relaxing factor, Nitric oxide, Rat aorta, Tannin",

author = "Hirozo Goto and Nobumitsu Tanaka and Kiyoaki Tanigawa and Yutaka Shimada and Takashi Itoh and Katsutoshi Terasawa",

year = "1997",

month = sep,

doi = "10.1002/(SICI)1099-1573(199709)11:6<457::AID-PTR123>3.0.CO;2-J",

language = "英語",

volume = "11",

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journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

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T1 - Endothelium-dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta

AU - Goto, Hirozo

AU - Tanaka, Nobumitsu

AU - Tanigawa, Kiyoaki

AU - Shimada, Yutaka

AU - Itoh, Takashi

AU - Terasawa, Katsutoshi

PY - 1997/9

Y1 - 1997/9

N2 - Arecae semen extract relaxed aortic ring preparations of isolated rat aorta that contained endothelium from 3x10-7 g/mL, reaching a maximum of 86% at 10-5 g/mL. Its relaxation did not occur in specimens without endothelium, and was inhibited by pretreatment with 10-4 M N(G)-nitro-1-arginine methylester. One of the active components was arecoline which is a muscarinic receptor agonist. Another active component was condensed tannin contained in Arecae semen.

AB - Arecae semen extract relaxed aortic ring preparations of isolated rat aorta that contained endothelium from 3x10-7 g/mL, reaching a maximum of 86% at 10-5 g/mL. Its relaxation did not occur in specimens without endothelium, and was inhibited by pretreatment with 10-4 M N(G)-nitro-1-arginine methylester. One of the active components was arecoline which is a muscarinic receptor agonist. Another active component was condensed tannin contained in Arecae semen.

KW - Arecae semen

KW - Arecoline

KW - Endothelium-dependent relaxing factor

KW - Nitric oxide

KW - Rat aorta

KW - Tannin

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DO - 10.1002/(SICI)1099-1573(199709)11:6<457::AID-PTR123>3.0.CO;2-J

M3 - 学術論文

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ER -

Endothelium-dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta

Abstract

Keywords

ASJC Scopus subject areas

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