Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells

Hideaki Yurino; Sho Ishikawa; Taku Sato; Kenji Akadegawa; Toshihiro Ito; Satoshi Ueha; Hidekuni Inadera; Kouji Matsushima

doi:10.1093/toxsci/kfh179

Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells

Hideaki Yurino, Sho Ishikawa, Taku Sato, Kenji Akadegawa, Toshihiro Ito, Satoshi Ueha, Hidekuni Inadera, Kouji Matsushima^*

^*Corresponding author for this work

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102 Scopus citations

Abstract

Accumulating data suggest that endocrine disruptors affect not only the reproductive system, but also the immune system. We demonstrate here that endocrine disruptors including diethylstilbestrol (DES) and bisphenol-A (BPA) enhance autoantibody production by B1 cells both in vitro and in vivo. BWF1 mice, a murine model for systemic lupus erythematosus (SLE), implanted with Silastic tubes containing DES after orchidectomy developed murine lupus characterized by immunoglobulin G (IgG) anti-DNA antibody production and IgG deposition in the glomeruli in the kidney as well as those implanted with 17β-estradiol (E2). Plaque-forming cells (PFC) producing autoantibodies specific for bromelain-treated red blood cells were significantly increased in mice implanted with DES and BPA. IgM antibody production by B1 cells in vitro was also enhanced in the presence of endocrine disruptors including DES and BPA. Estrogen receptor (ER) expression was upregulated in B1 cells in aged BWF1 mice that developed lupus nephritis. These results suggest that endocrine disruptors are involved in autoantibody production by B1 cells and may be an etiologic factor in the development of autoimmune diseases.

Original language	English
Pages (from-to)	139-147
Number of pages	9
Journal	Toxicological Sciences
Volume	81
Issue number	1
DOIs	https://doi.org/10.1093/toxsci/kfh179
State	Published - 2004/09

Keywords

Autoantibody
B cell
Endocrine disruptors
Environmental estrogens
SLE
Systemic lupus erythematosus

ASJC Scopus subject areas

Toxicology

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10.1093/toxsci/kfh179

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title = "Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells",

abstract = "Accumulating data suggest that endocrine disruptors affect not only the reproductive system, but also the immune system. We demonstrate here that endocrine disruptors including diethylstilbestrol (DES) and bisphenol-A (BPA) enhance autoantibody production by B1 cells both in vitro and in vivo. BWF1 mice, a murine model for systemic lupus erythematosus (SLE), implanted with Silastic tubes containing DES after orchidectomy developed murine lupus characterized by immunoglobulin G (IgG) anti-DNA antibody production and IgG deposition in the glomeruli in the kidney as well as those implanted with 17β-estradiol (E2). Plaque-forming cells (PFC) producing autoantibodies specific for bromelain-treated red blood cells were significantly increased in mice implanted with DES and BPA. IgM antibody production by B1 cells in vitro was also enhanced in the presence of endocrine disruptors including DES and BPA. Estrogen receptor (ER) expression was upregulated in B1 cells in aged BWF1 mice that developed lupus nephritis. These results suggest that endocrine disruptors are involved in autoantibody production by B1 cells and may be an etiologic factor in the development of autoimmune diseases.",

keywords = "Autoantibody, B cell, Endocrine disruptors, Environmental estrogens, SLE, Systemic lupus erythematosus",

author = "Hideaki Yurino and Sho Ishikawa and Taku Sato and Kenji Akadegawa and Toshihiro Ito and Satoshi Ueha and Hidekuni Inadera and Kouji Matsushima",

note = "Funding Information: This work was supported by SORST (Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation) and LRI (The Long-Range Research Initiative, Japan).",

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AU - Yurino, Hideaki

AU - Ishikawa, Sho

AU - Sato, Taku

AU - Akadegawa, Kenji

AU - Ito, Toshihiro

AU - Ueha, Satoshi

AU - Inadera, Hidekuni

AU - Matsushima, Kouji

N1 - Funding Information: This work was supported by SORST (Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation) and LRI (The Long-Range Research Initiative, Japan).

PY - 2004/9

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N2 - Accumulating data suggest that endocrine disruptors affect not only the reproductive system, but also the immune system. We demonstrate here that endocrine disruptors including diethylstilbestrol (DES) and bisphenol-A (BPA) enhance autoantibody production by B1 cells both in vitro and in vivo. BWF1 mice, a murine model for systemic lupus erythematosus (SLE), implanted with Silastic tubes containing DES after orchidectomy developed murine lupus characterized by immunoglobulin G (IgG) anti-DNA antibody production and IgG deposition in the glomeruli in the kidney as well as those implanted with 17β-estradiol (E2). Plaque-forming cells (PFC) producing autoantibodies specific for bromelain-treated red blood cells were significantly increased in mice implanted with DES and BPA. IgM antibody production by B1 cells in vitro was also enhanced in the presence of endocrine disruptors including DES and BPA. Estrogen receptor (ER) expression was upregulated in B1 cells in aged BWF1 mice that developed lupus nephritis. These results suggest that endocrine disruptors are involved in autoantibody production by B1 cells and may be an etiologic factor in the development of autoimmune diseases.

AB - Accumulating data suggest that endocrine disruptors affect not only the reproductive system, but also the immune system. We demonstrate here that endocrine disruptors including diethylstilbestrol (DES) and bisphenol-A (BPA) enhance autoantibody production by B1 cells both in vitro and in vivo. BWF1 mice, a murine model for systemic lupus erythematosus (SLE), implanted with Silastic tubes containing DES after orchidectomy developed murine lupus characterized by immunoglobulin G (IgG) anti-DNA antibody production and IgG deposition in the glomeruli in the kidney as well as those implanted with 17β-estradiol (E2). Plaque-forming cells (PFC) producing autoantibodies specific for bromelain-treated red blood cells were significantly increased in mice implanted with DES and BPA. IgM antibody production by B1 cells in vitro was also enhanced in the presence of endocrine disruptors including DES and BPA. Estrogen receptor (ER) expression was upregulated in B1 cells in aged BWF1 mice that developed lupus nephritis. These results suggest that endocrine disruptors are involved in autoantibody production by B1 cells and may be an etiologic factor in the development of autoimmune diseases.

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Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells

Abstract

Keywords

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