Emerging impacts of biological methylation on genetic information

Koichiro Kako, Jun Dal Kim, Akiyoshi Fukamizu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

The central dogma of molecular biology explains the fundamental flow of genetic information for life. Although genome sequence (DNA) itself is a static chemical signature, it includes multiple layers of information composed of mRNA, tRNA, rRNA and small RNAs, all of which are involved in protein synthesis and is passing from parents to offspring via DNA. Methylation is a biologically important modification, because DNA, RNAs and proteins, components of the central dogma, are methylated by a set of methyltransferases. Recent works focused on understanding a variety of biological methylation have shed light on new regulation of cellular functions. In this review, we briefly discuss some of those recent findings of methylation, including DNA, RNAs and proteins.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalJournal of Biochemistry
Volume165
Issue number1
DOIs
StatePublished - 2019/01/01

Keywords

  • biological methylation
  • central dogma
  • demethylase
  • methyltransferase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Emerging impacts of biological methylation on genetic information'. Together they form a unique fingerprint.

Cite this