Abstract
The oxidative cleavage reaction of pyrrolidine-2-methanols to γ-lactams has been described. In this reaction, [4-iodo-3-(isopropylcarbamoyl)phenoxy]acetic acid and powdered Oxone (2KHSO5·KHSO4·K2SO4) were employed as the catalyst and co-oxidant, respectively. The reaction is efficient and environmentally benign because it produces various lactams from readily available substrates in moderate to excellent yields using organocatalyst and inorganic non-toxic co-oxidant.
Original language | English |
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Pages (from-to) | 75-79 |
Number of pages | 5 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 72 |
Issue number | 1 |
DOIs | |
State | Published - 2024/01/01 |
Keywords
- Oxone
- environmentally benign oxidation
- hypervalent iodine
- lactam
- oxidative cleavage
ASJC Scopus subject areas
- General Chemistry
- Drug Discovery