Effects of structural modification of calcium spirulan, a sulfated polysaccharide from Spirulina Platensis, on antiviral activity

J. B. Lee, P. Srisomporn, K. Hayashi, T. Tanaka, U. Sankawa, T. Hayashi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Calcium ion binding with the anionic part of a molecule was replaced with various metal cations and their inhibitory effects on the replication of herpes simplex virus type 1 were evaluated. Replacement of calcium ion with sodium and potassium ions maintained the antiviral activity while divalent and trivalent metal cations reduced the activity. Depolymerization of sodium spirulan with hydrogen peroxide decreased in antiviral activity as its molecular weight decreased.

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume49
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Antiviral activity
  • Calcium spirulan
  • Depolymerization
  • HSV-1
  • Metal cation
  • Sulfated polysaccharide

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Effects of structural modification of calcium spirulan, a sulfated polysaccharide from Spirulina Platensis, on antiviral activity'. Together they form a unique fingerprint.

Cite this