Effects of isopropyl unoprostone, latanoprost, and prostaglandin E2 on acute rise of aqueous flare in pigmented rabbits

Xue Yun Zhang; Seiji Hayasaka; Yoriko Hayasaka; Shuichiro Yanagisawa; Yasunori Nagaki

doi:10.1159/000048334

Effects of isopropyl unoprostone, latanoprost, and prostaglandin E₂ on acute rise of aqueous flare in pigmented rabbits

Xue Yun Zhang^*, Seiji Hayasaka, Yoriko Hayasaka, Shuichiro Yanagisawa, Yasunori Nagaki

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Purpose: To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E₂ (PGE₂) on aqueous flare elevation. Methods: Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE₂, 25 μg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter. Results: Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE₂. Latanoprost did not induce flare elevation. Conclusion: Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.

Original language	English
Pages (from-to)	90-93
Number of pages	4
Journal	Ophthalmic Research
Volume	34
Issue number	2
DOIs	https://doi.org/10.1159/000048334
State	Published - 2002

Keywords

Aqueous flare
Isopropyl unoprostone
Latanoprost
Prostaglandin E
Rabbit

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

10.1159/000048334

Cite this

@article{e8115bdc461f42699798e6822242630d,

title = "Effects of isopropyl unoprostone, latanoprost, and prostaglandin E2 on acute rise of aqueous flare in pigmented rabbits",

abstract = "Purpose: To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E2 (PGE2) on aqueous flare elevation. Methods: Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE2, 25 μg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter. Results: Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE2. Latanoprost did not induce flare elevation. Conclusion: Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.",

keywords = "Aqueous flare, Isopropyl unoprostone, Latanoprost, Prostaglandin E, Rabbit",

author = "Zhang, {Xue Yun} and Seiji Hayasaka and Yoriko Hayasaka and Shuichiro Yanagisawa and Yasunori Nagaki",

year = "2002",

doi = "10.1159/000048334",

language = "英語",

volume = "34",

pages = "90--93",

journal = "Ophthalmic Research",

issn = "0030-3747",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Effects of isopropyl unoprostone, latanoprost, and prostaglandin E2 on acute rise of aqueous flare in pigmented rabbits

AU - Zhang, Xue Yun

AU - Hayasaka, Seiji

AU - Hayasaka, Yoriko

AU - Yanagisawa, Shuichiro

AU - Nagaki, Yasunori

PY - 2002

Y1 - 2002

N2 - Purpose: To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E2 (PGE2) on aqueous flare elevation. Methods: Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE2, 25 μg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter. Results: Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE2. Latanoprost did not induce flare elevation. Conclusion: Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.

AB - Purpose: To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E2 (PGE2) on aqueous flare elevation. Methods: Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE2, 25 μg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter. Results: Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE2. Latanoprost did not induce flare elevation. Conclusion: Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.

KW - Aqueous flare

KW - Isopropyl unoprostone

KW - Latanoprost

KW - Prostaglandin E

KW - Rabbit

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DO - 10.1159/000048334

M3 - 学術論文

C2 - 11914611

AN - SCOPUS:0036201698

SN - 0030-3747

VL - 34

SP - 90

EP - 93

JO - Ophthalmic Research

JF - Ophthalmic Research

IS - 2

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