TY - JOUR
T1 - Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney
AU - Kuriwaki, Jun Ichi
AU - Nishijo, Muneko
AU - Honda, Ryumon
AU - Tawara, Kenji
AU - Nakagawa, Hideaki
AU - Hori, Etsuro
AU - Nishijo, Hisao
N1 - Funding Information:
This work was supported by grant for project research from High Technology Center of Kanazawa Medical University (H2002-4).
PY - 2005/4/28
Y1 - 2005/4/28
N2 - Female rats were exposed by intragastric administration with a cannula 1 mg/kg/day or 10 mg/kg/day CdCl2 for the 11 days from the 9th to 19th day of pregnancy, and the effects of Cd exposure on eight elements, Na, K, Ca, Mg, P, Fe, Zn, and Cu in fetal liver, kidney, brain, fetal membrane and placenta then examined. We found that: (1) although Cd was not detected in fetal kidney and brain, significant Cd accumulation was found in fetal liver, fetal membrane and placenta in the 10 mg/kg Cd group, (2) the Zn and Fe concentrations in fetal liver in the 10 mg/kg Cd group were significantly lower than those in the control group, but no difference was found in the placenta, (3) the Cu concentrations in the placenta, fetal membrane and liver in the 10 mg Cd groups were significantly lower than those in the control group, (4) Na/K ratio in the placenta and fetal kidney and the Ca concentration in the placenta in the 10 mg/kg Cd group were lower than those in the controls. These results suggest that Cd exposure inhibits Zn and Fe transportation from the placenta to fetus, as well as Cu, Ca, Na and K uptake and transportation across the placenta, possibly influencing fetal growth and metabolism.
AB - Female rats were exposed by intragastric administration with a cannula 1 mg/kg/day or 10 mg/kg/day CdCl2 for the 11 days from the 9th to 19th day of pregnancy, and the effects of Cd exposure on eight elements, Na, K, Ca, Mg, P, Fe, Zn, and Cu in fetal liver, kidney, brain, fetal membrane and placenta then examined. We found that: (1) although Cd was not detected in fetal kidney and brain, significant Cd accumulation was found in fetal liver, fetal membrane and placenta in the 10 mg/kg Cd group, (2) the Zn and Fe concentrations in fetal liver in the 10 mg/kg Cd group were significantly lower than those in the control group, but no difference was found in the placenta, (3) the Cu concentrations in the placenta, fetal membrane and liver in the 10 mg Cd groups were significantly lower than those in the control group, (4) Na/K ratio in the placenta and fetal kidney and the Ca concentration in the placenta in the 10 mg/kg Cd group were lower than those in the controls. These results suggest that Cd exposure inhibits Zn and Fe transportation from the placenta to fetus, as well as Cu, Ca, Na and K uptake and transportation across the placenta, possibly influencing fetal growth and metabolism.
KW - Cadmium
KW - Fetus
KW - Mineral
KW - Placenta
KW - Rat
KW - Trace element
UR - http://www.scopus.com/inward/record.url?scp=14844321944&partnerID=8YFLogxK
U2 - 10.1016/j.toxlet.2004.12.009
DO - 10.1016/j.toxlet.2004.12.009
M3 - 学術論文
C2 - 15763636
AN - SCOPUS:14844321944
SN - 0378-4274
VL - 156
SP - 369
EP - 376
JO - Toxicology Letters
JF - Toxicology Letters
IS - 3
ER -