TY - JOUR
T1 - Effect of the natural fragrance "cedrol" on dopamine metabolism in the lateral hypothalamic area of restrained rats
T2 - A microdialysis study
AU - Akutsu, Taishi
AU - Tanaka, Satoshi
AU - Murakami, Yoshihiro
AU - Nakajima, Kazuki
AU - Nagashima, Yoshinao
AU - Yada, Yukihiro
AU - Suzuki, Toshiyuki
AU - Sasaki, Kazuo
N1 - Funding Information:
This work was partly supported by a Grant-in-Aid (No. 17500467) and a Special Coordination Fund for Promoting Science and Technology from the Japanese Ministry of Education, Culture, Sports, Science and Technology. One of the authors (K.S.) offers special thanks to Mr. Chikamitsu Nakayama for his encouragement throughout this work.
PY - 2006/4
Y1 - 2006/4
N2 - It has been reported that cedrol, a natural crystalline substance derived from cedar wood oil, has sedative effects on behavioral and autonomic activities in animals. In the present study, the effect of cedrol on dopamine (DA) metabolism was investigated in the lateral hypothalamic area (LHA) of restrained rats using an in vivo microdialysis technique. Immobilization stress increased DA release in the LHA with concomitantly large increases in 3,4 hydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels, indicating that it activates the dopaminergic system in the brain. When the rats were exposed to cedrol, DA release was unchanged during and after immobilization stress compared with the basal level. The DOPAC and HVA levels showed only small increases during immobilization stress, and almost returned to basal levels after immobilization stress. The present results indicate that cedrol inhibits an increase in dopamine metabolism induced by immobilization stress, and suggest that the sedative effects of cedrol on behavioral and autonomic activities are partly due to the inhibition of dopaminergic neurotransmission and the modulation of LHA neuron activity by DA.
AB - It has been reported that cedrol, a natural crystalline substance derived from cedar wood oil, has sedative effects on behavioral and autonomic activities in animals. In the present study, the effect of cedrol on dopamine (DA) metabolism was investigated in the lateral hypothalamic area (LHA) of restrained rats using an in vivo microdialysis technique. Immobilization stress increased DA release in the LHA with concomitantly large increases in 3,4 hydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels, indicating that it activates the dopaminergic system in the brain. When the rats were exposed to cedrol, DA release was unchanged during and after immobilization stress compared with the basal level. The DOPAC and HVA levels showed only small increases during immobilization stress, and almost returned to basal levels after immobilization stress. The present results indicate that cedrol inhibits an increase in dopamine metabolism induced by immobilization stress, and suggest that the sedative effects of cedrol on behavioral and autonomic activities are partly due to the inhibition of dopaminergic neurotransmission and the modulation of LHA neuron activity by DA.
KW - Cedrol
KW - Dopamine metabolism
KW - Immobilization stress
KW - In vivo microdialysis
KW - Lateral hypothalamic area
KW - Plant-derived odor
UR - http://www.scopus.com/inward/record.url?scp=33646538126&partnerID=8YFLogxK
U2 - 10.1016/j.ics.2005.12.020
DO - 10.1016/j.ics.2005.12.020
M3 - 学術論文
AN - SCOPUS:33646538126
SN - 0531-5131
VL - 1287
SP - 195
EP - 200
JO - International Congress Series
JF - International Congress Series
ER -