Effect of phospholipase Cβ4 lacking in thalamic neurons on electroencephalogram

Miho Kameyama; Isao Yamaguchi; Kazuhisa Ichikawa; Takashi Sugiyama; Moritoshi Hirono; Hirokazu Hori; Masayuki Ikeda; Yuko Kuwahata; Naomi Eguchi; Yoshihiro Urade; Tohru Yoshioka

doi:10.1016/S0006-291X(03)00536-9

Effect of phospholipase Cβ4 lacking in thalamic neurons on electroencephalogram

Miho Kameyama, Isao Yamaguchi, Kazuhisa Ichikawa, Takashi Sugiyama, Moritoshi Hirono, Hirokazu Hori, Masayuki Ikeda, Yuko Kuwahata, Naomi Eguchi, Yoshihiro Urade, Tohru Yoshioka^*

^*Corresponding author for this work

Member of the Board

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cβ4 (PLCβ4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we investigated the role of PLCβ4 in thalamic neuron. PLCβ4-deficient mutant mice were found to exhibit three phenotypic characteristics: (1) a 2-Hz increase in the peak frequency of electroencephalogram (EEG) of rapid eye movement (REM) sleep, (2) an increase in the frequency of miniature excitatory postsynaptic currents (mEPSCs) recorded in thalamus, and (3) waveform distortion of EEG. We postulate here that changes in protein phosphorylation due to reduced cPKC activity by PLCβ4 deletion in thalamic neurons may give rise to these phenotypic characteristics. Taken together, these results indicate that reduced PLCβ4 activity in thalamic neurons may underlie high-cortical oscillation frequency.

Original language	English
Pages (from-to)	153-159
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	304
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(03)00536-9
State	Published - 2003/04/25

Keywords

EEG
FFT
LGNd
Mouse
PLCβ4
PST
Thalamus
mEPSC

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Effect of phospholipase Cβ4 lacking in thalamic neurons on electroencephalogram",

abstract = "Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cβ4 (PLCβ4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we investigated the role of PLCβ4 in thalamic neuron. PLCβ4-deficient mutant mice were found to exhibit three phenotypic characteristics: (1) a 2-Hz increase in the peak frequency of electroencephalogram (EEG) of rapid eye movement (REM) sleep, (2) an increase in the frequency of miniature excitatory postsynaptic currents (mEPSCs) recorded in thalamus, and (3) waveform distortion of EEG. We postulate here that changes in protein phosphorylation due to reduced cPKC activity by PLCβ4 deletion in thalamic neurons may give rise to these phenotypic characteristics. Taken together, these results indicate that reduced PLCβ4 activity in thalamic neurons may underlie high-cortical oscillation frequency.",

keywords = "EEG, FFT, LGNd, Mouse, PLCβ4, PST, Thalamus, mEPSC",

author = "Miho Kameyama and Isao Yamaguchi and Kazuhisa Ichikawa and Takashi Sugiyama and Moritoshi Hirono and Hirokazu Hori and Masayuki Ikeda and Yuko Kuwahata and Naomi Eguchi and Yoshihiro Urade and Tohru Yoshioka",

note = "Funding Information: This work was supported by Research for the Future Program (96L00310) to T.Y. from Japan Society for the Promotion of Science.",

year = "2003",

month = apr,

day = "25",

doi = "10.1016/S0006-291X(03)00536-9",

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pages = "153--159",

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TY - JOUR

T1 - Effect of phospholipase Cβ4 lacking in thalamic neurons on electroencephalogram

AU - Kameyama, Miho

AU - Yamaguchi, Isao

AU - Ichikawa, Kazuhisa

AU - Sugiyama, Takashi

AU - Hirono, Moritoshi

AU - Hori, Hirokazu

AU - Ikeda, Masayuki

AU - Kuwahata, Yuko

AU - Eguchi, Naomi

AU - Urade, Yoshihiro

AU - Yoshioka, Tohru

N1 - Funding Information: This work was supported by Research for the Future Program (96L00310) to T.Y. from Japan Society for the Promotion of Science.

PY - 2003/4/25

Y1 - 2003/4/25

N2 - Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cβ4 (PLCβ4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we investigated the role of PLCβ4 in thalamic neuron. PLCβ4-deficient mutant mice were found to exhibit three phenotypic characteristics: (1) a 2-Hz increase in the peak frequency of electroencephalogram (EEG) of rapid eye movement (REM) sleep, (2) an increase in the frequency of miniature excitatory postsynaptic currents (mEPSCs) recorded in thalamus, and (3) waveform distortion of EEG. We postulate here that changes in protein phosphorylation due to reduced cPKC activity by PLCβ4 deletion in thalamic neurons may give rise to these phenotypic characteristics. Taken together, these results indicate that reduced PLCβ4 activity in thalamic neurons may underlie high-cortical oscillation frequency.

AB - Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cβ4 (PLCβ4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we investigated the role of PLCβ4 in thalamic neuron. PLCβ4-deficient mutant mice were found to exhibit three phenotypic characteristics: (1) a 2-Hz increase in the peak frequency of electroencephalogram (EEG) of rapid eye movement (REM) sleep, (2) an increase in the frequency of miniature excitatory postsynaptic currents (mEPSCs) recorded in thalamus, and (3) waveform distortion of EEG. We postulate here that changes in protein phosphorylation due to reduced cPKC activity by PLCβ4 deletion in thalamic neurons may give rise to these phenotypic characteristics. Taken together, these results indicate that reduced PLCβ4 activity in thalamic neurons may underlie high-cortical oscillation frequency.

KW - EEG

KW - FFT

KW - LGNd

KW - Mouse

KW - PLCβ4

KW - PST

KW - Thalamus

KW - mEPSC

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Effect of phospholipase Cβ4 lacking in thalamic neurons on electroencephalogram

Abstract

Keywords

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