Effect of dietary α-linolenate/linoleate balance on endotoxin-induced hepatitis in mice

Shiro Watanabe*, Harumi Okuyama

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Mice were fed diets with three different ratios of α-linolenate (18:-3) to linoleate (18:2n-6), and the severity of hepatitis during endotoxic shock was compared. Dietary enrichment with α-linolenate increased the severity of hepatitis and the mortality induced by lipopolysaccharide (LPS) in combination with D-galactosamine (GalN). Differences in the dietary α-linolenate/linoleate balance were mainly reflected in the levels of arachidonate and eicosapenatenoate in liver phospholipids. Pretreatement of mice with indomethacin was found to also enhance the severity of GalN/LPS-hepatitis. This indicated that cyclooxygenase products of arachidonate may suppress the development of GalN/LPS-hepatitis. The enhancement by high α-linolenate diets was not observed when a lethal dose of LPS in the absence of GalN was given. Our results indicate that there are pathophysiological conditions of endotoxin-induced hepatitis under which cyclooxygenase products of arachidonate play protective roles.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalLipids
Volume26
Issue number6
DOIs
StatePublished - 1991/06

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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