Abstract
Mice were fed diets with three different ratios of α-linolenate (18:-3) to linoleate (18:2n-6), and the severity of hepatitis during endotoxic shock was compared. Dietary enrichment with α-linolenate increased the severity of hepatitis and the mortality induced by lipopolysaccharide (LPS) in combination with D-galactosamine (GalN). Differences in the dietary α-linolenate/linoleate balance were mainly reflected in the levels of arachidonate and eicosapenatenoate in liver phospholipids. Pretreatement of mice with indomethacin was found to also enhance the severity of GalN/LPS-hepatitis. This indicated that cyclooxygenase products of arachidonate may suppress the development of GalN/LPS-hepatitis. The enhancement by high α-linolenate diets was not observed when a lethal dose of LPS in the absence of GalN was given. Our results indicate that there are pathophysiological conditions of endotoxin-induced hepatitis under which cyclooxygenase products of arachidonate play protective roles.
Original language | English |
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Pages (from-to) | 467-471 |
Number of pages | 5 |
Journal | Lipids |
Volume | 26 |
Issue number | 6 |
DOIs | |
State | Published - 1991/06 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Cell Biology