TY - JOUR
T1 - Effect of Choto-san, a Kampo medicine, on impairment of passive avoidance performance in mice
AU - Yuzurihara, Mitsutoshi
AU - Goto, Kazuhiro
AU - Sugimoto, Akira
AU - Ishige, Atsushi
AU - Komatsu, Yasuhiro
AU - Shimada, Yutaka
AU - Terasawa, Katsutoshi
PY - 1999/5
Y1 - 1999/5
N2 - In mice with procephalic ischaemia loading, disrupted passive avoidance retention performance was dose-dependently improved by Choto-san, but this effect was antagonized by NAN-190, a serotonin(1A) receptor antagonist. In mice with decreased intracerebral serotonin concentration, Choto-san prevented disturbance in acquiring a passive avoidance response after scopolamine administration, but did not influence the decreased serotonin concentration. These results suggested that Choto-san showed the anti-amnestic effect based on the stimulation of serotonin(1A) receptors.
AB - In mice with procephalic ischaemia loading, disrupted passive avoidance retention performance was dose-dependently improved by Choto-san, but this effect was antagonized by NAN-190, a serotonin(1A) receptor antagonist. In mice with decreased intracerebral serotonin concentration, Choto-san prevented disturbance in acquiring a passive avoidance response after scopolamine administration, but did not influence the decreased serotonin concentration. These results suggested that Choto-san showed the anti-amnestic effect based on the stimulation of serotonin(1A) receptors.
KW - Cerebrovascular dementia
KW - Choto-san
KW - Passive avoidance task
KW - Serotonergic system
KW - Serotonin(1A) receptor
UR - http://www.scopus.com/inward/record.url?scp=0032893005&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-1573(199905)13:3<233::AID-PTR416>3.0.CO;2-R
DO - 10.1002/(SICI)1099-1573(199905)13:3<233::AID-PTR416>3.0.CO;2-R
M3 - 学術論文
C2 - 10353166
AN - SCOPUS:0032893005
SN - 0951-418X
VL - 13
SP - 233
EP - 235
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 3
ER -