Effect of charcoal hemoperfusion for removal of plasma methotrexate in a patient with acute renal failure

Tae Nemoto; Chihaya Imai; Utako Kaneko; Takayuki Takachi; Haruko Iwabuchi; Atsushi Tanaka; Gen Nakamura; Akira Ogose; Makoto Uchiyama

doi:10.1080/08880010902976023

Effect of charcoal hemoperfusion for removal of plasma methotrexate in a patient with acute renal failure

Tae Nemoto^*, Chihaya Imai, Utako Kaneko, Takayuki Takachi, Haruko Iwabuchi, Atsushi Tanaka, Gen Nakamura, Akira Ogose, Makoto Uchiyama

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Strategies effective for accelerating methotrexate removal in delayed methotrexate excretion have not been universally accepted. The authors report a case of a 12-year-old girl with osteosarcoma who developed acute renal failure immediately after the first administration of high-dose methotrexate. Plasma methotrexate was effectively removed with repeated charcoal hemoperfusion in addition to plasma exchange and leucovorin rescue. Charcoal hemoperfusion was most effective for reducing plasma methotrexate with approximately 50% of methotrexate being reduced during each of the procedures. No rebound increase in MTX levels was observed. The patient received further therapy with other cancer drugs and has been well for 3.5 years.

Original language	English
Pages (from-to)	520-525
Number of pages	6
Journal	Pediatric Hematology and Oncology
Volume	26
Issue number	7
DOIs	https://doi.org/10.1080/08880010902976023
State	Published - 2009

Keywords

Acute renal failure
Charcoal hemoperfusion
High-dose methotrexate
Leucovorin
Osteosarcoma
Plasma exchange

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/08880010902976023

Cite this

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title = "Effect of charcoal hemoperfusion for removal of plasma methotrexate in a patient with acute renal failure",

abstract = "Strategies effective for accelerating methotrexate removal in delayed methotrexate excretion have not been universally accepted. The authors report a case of a 12-year-old girl with osteosarcoma who developed acute renal failure immediately after the first administration of high-dose methotrexate. Plasma methotrexate was effectively removed with repeated charcoal hemoperfusion in addition to plasma exchange and leucovorin rescue. Charcoal hemoperfusion was most effective for reducing plasma methotrexate with approximately 50% of methotrexate being reduced during each of the procedures. No rebound increase in MTX levels was observed. The patient received further therapy with other cancer drugs and has been well for 3.5 years.",

keywords = "Acute renal failure, Charcoal hemoperfusion, High-dose methotrexate, Leucovorin, Osteosarcoma, Plasma exchange",

author = "Tae Nemoto and Chihaya Imai and Utako Kaneko and Takayuki Takachi and Haruko Iwabuchi and Atsushi Tanaka and Gen Nakamura and Akira Ogose and Makoto Uchiyama",

year = "2009",

doi = "10.1080/08880010902976023",

language = "英語",

volume = "26",

pages = "520--525",

journal = "Pediatric Hematology and Oncology",

issn = "0888-0018",

publisher = "Informa Healthcare",

number = "7",

}

TY - JOUR

T1 - Effect of charcoal hemoperfusion for removal of plasma methotrexate in a patient with acute renal failure

AU - Nemoto, Tae

AU - Imai, Chihaya

AU - Kaneko, Utako

AU - Takachi, Takayuki

AU - Iwabuchi, Haruko

AU - Tanaka, Atsushi

AU - Nakamura, Gen

AU - Ogose, Akira

AU - Uchiyama, Makoto

PY - 2009

Y1 - 2009

N2 - Strategies effective for accelerating methotrexate removal in delayed methotrexate excretion have not been universally accepted. The authors report a case of a 12-year-old girl with osteosarcoma who developed acute renal failure immediately after the first administration of high-dose methotrexate. Plasma methotrexate was effectively removed with repeated charcoal hemoperfusion in addition to plasma exchange and leucovorin rescue. Charcoal hemoperfusion was most effective for reducing plasma methotrexate with approximately 50% of methotrexate being reduced during each of the procedures. No rebound increase in MTX levels was observed. The patient received further therapy with other cancer drugs and has been well for 3.5 years.

AB - Strategies effective for accelerating methotrexate removal in delayed methotrexate excretion have not been universally accepted. The authors report a case of a 12-year-old girl with osteosarcoma who developed acute renal failure immediately after the first administration of high-dose methotrexate. Plasma methotrexate was effectively removed with repeated charcoal hemoperfusion in addition to plasma exchange and leucovorin rescue. Charcoal hemoperfusion was most effective for reducing plasma methotrexate with approximately 50% of methotrexate being reduced during each of the procedures. No rebound increase in MTX levels was observed. The patient received further therapy with other cancer drugs and has been well for 3.5 years.

KW - Acute renal failure

KW - Charcoal hemoperfusion

KW - High-dose methotrexate

KW - Leucovorin

KW - Osteosarcoma

KW - Plasma exchange

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U2 - 10.1080/08880010902976023

DO - 10.1080/08880010902976023

M3 - 学術論文

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AN - SCOPUS:70350072831

SN - 0888-0018

VL - 26

SP - 520

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JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

IS - 7

ER -

Effect of charcoal hemoperfusion for removal of plasma methotrexate in a patient with acute renal failure

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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