Double Leukemias Simultaneously Showing Lymphoblastic Leukemia of the Bone Marrow and Monocytic Leukemia of the Central Nervous System

Yukie Ikarashi; Toshio Kakihara; Chihaya Imai; Atsushi Tanaka; Akihiro Watanabe; Makoto Uchiyama

doi:10.1002/ajh.10478

Double Leukemias Simultaneously Showing Lymphoblastic Leukemia of the Bone Marrow and Monocytic Leukemia of the Central Nervous System

Yukie Ikarashi, Toshio Kakihara^*, Chihaya Imai, Atsushi Tanaka, Akihiro Watanabe, Makoto Uchiyama

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. A 4-year-old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy-related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	American Journal of Hematology
Volume	75
Issue number	3
DOIs	https://doi.org/10.1002/ajh.10478
State	Published - 2004/03

Keywords

Central nervous system
Double leukemias
Lineage switch
Mixed leukemia

ASJC Scopus subject areas

Hematology

Access to Document

10.1002/ajh.10478

Cite this

@article{5c6fab072b584a23a37843494bd86b53,

title = "Double Leukemias Simultaneously Showing Lymphoblastic Leukemia of the Bone Marrow and Monocytic Leukemia of the Central Nervous System",

abstract = "A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. A 4-year-old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy-related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites.",

keywords = "Central nervous system, Double leukemias, Lineage switch, Mixed leukemia",

author = "Yukie Ikarashi and Toshio Kakihara and Chihaya Imai and Atsushi Tanaka and Akihiro Watanabe and Makoto Uchiyama",

year = "2004",

month = mar,

doi = "10.1002/ajh.10478",

language = "英語",

volume = "75",

pages = "164--167",

journal = "American Journal of Hematology",

issn = "0361-8609",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Double Leukemias Simultaneously Showing Lymphoblastic Leukemia of the Bone Marrow and Monocytic Leukemia of the Central Nervous System

AU - Ikarashi, Yukie

AU - Kakihara, Toshio

AU - Imai, Chihaya

AU - Tanaka, Atsushi

AU - Watanabe, Akihiro

AU - Uchiyama, Makoto

PY - 2004/3

Y1 - 2004/3

N2 - A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. A 4-year-old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy-related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites.

AB - A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. A 4-year-old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy-related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites.

KW - Central nervous system

KW - Double leukemias

KW - Lineage switch

KW - Mixed leukemia

UR - http://www.scopus.com/inward/record.url?scp=1342344858&partnerID=8YFLogxK

U2 - 10.1002/ajh.10478

DO - 10.1002/ajh.10478

M3 - 学術論文

C2 - 14978698

AN - SCOPUS:1342344858

SN - 0361-8609

VL - 75

SP - 164

EP - 167

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 3

ER -

Double Leukemias Simultaneously Showing Lymphoblastic Leukemia of the Bone Marrow and Monocytic Leukemia of the Central Nervous System

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this