TY - JOUR
T1 - Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP
T2 - a nested case–control study
AU - Yoshimura, Masaru
AU - Fujieda, Yuichiro
AU - Sugawara, Masanari
AU - Kono, Michihito
AU - Kato, Masaru
AU - Yokota, Isao
AU - Amengual, Olga
AU - Ito, Yoichi M.
AU - Atsumi, Tatsuya
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/11
Y1 - 2022/11
N2 - The objective of this study is to clarify the clinical features and risk factors of venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA). We retrospectively reviewed the prevalence of VTE in RA patients who visited Hokkaido University Hospital from 2010 to 2019 and had more than 2 years of follow-up. To explore the risk to develop VTE, we selected 260 RA patients without VTE (non-VTE) via density sampling and identified the risk factors for VTE by multivariate logistic regression analysis. Univariate conditional logistic regression analysis showed older age (p < 0.0001, Odds Ratio [OR] 1.08, 95% Confidence Interval [CI] 1.04–1.14), increase of the body mass index (BMI) (p = 0.001, OR 1.17, 95% CI 1.06–1.31), higher prevalence of RA-associated lung disease (p = 0.002, OR 2.10, 95% CI 1.33–3.30) and more frequent glucocorticoid usage (p = 0.001, OR 2.09, 95% CI 1.34–3.51) in RA patients was associated with the development of VTE significantly. Furthermore, patients with higher time-averaged disease activity score 28 (DAS28) CRP were at elevated risk (p < 0.0001, OR 3.25, 95% CI 1.94–6.12). In conditional multivariate logistic regression analysis, time averaged DAS28CRP was significantly associated with the development of VTE (p = 0.0001, adjusted OR 3.40, 95% CI 1.77–7.85). Disease activity was identified as a major risk factor of VTE in patients with RA, suggesting that sustained clinical remission could be beneficial for decrease the risk of VTE.
AB - The objective of this study is to clarify the clinical features and risk factors of venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA). We retrospectively reviewed the prevalence of VTE in RA patients who visited Hokkaido University Hospital from 2010 to 2019 and had more than 2 years of follow-up. To explore the risk to develop VTE, we selected 260 RA patients without VTE (non-VTE) via density sampling and identified the risk factors for VTE by multivariate logistic regression analysis. Univariate conditional logistic regression analysis showed older age (p < 0.0001, Odds Ratio [OR] 1.08, 95% Confidence Interval [CI] 1.04–1.14), increase of the body mass index (BMI) (p = 0.001, OR 1.17, 95% CI 1.06–1.31), higher prevalence of RA-associated lung disease (p = 0.002, OR 2.10, 95% CI 1.33–3.30) and more frequent glucocorticoid usage (p = 0.001, OR 2.09, 95% CI 1.34–3.51) in RA patients was associated with the development of VTE significantly. Furthermore, patients with higher time-averaged disease activity score 28 (DAS28) CRP were at elevated risk (p < 0.0001, OR 3.25, 95% CI 1.94–6.12). In conditional multivariate logistic regression analysis, time averaged DAS28CRP was significantly associated with the development of VTE (p = 0.0001, adjusted OR 3.40, 95% CI 1.77–7.85). Disease activity was identified as a major risk factor of VTE in patients with RA, suggesting that sustained clinical remission could be beneficial for decrease the risk of VTE.
KW - Disease activity
KW - Rheumatoid arthritis
KW - Time-averaged DAS28CRP
KW - Venous thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=85138804613&partnerID=8YFLogxK
U2 - 10.1007/s00296-022-05121-4
DO - 10.1007/s00296-022-05121-4
M3 - 学術論文
C2 - 35384451
AN - SCOPUS:85138804613
SN - 0172-8172
VL - 42
SP - 1939
EP - 1946
JO - Rheumatology International
JF - Rheumatology International
IS - 11
ER -