Abstract
Cyclic voltammetry was performed at various scan rates for the duplexes from ferrocene/isoquinoline conjugate-connected DNA probes on gold electrodes. The relationship between the observed currents and the scan rates disclosed the enhanced bending elasticity of the mismatched duplexes compared with the fully matched duplexes. The difference of the dynamics was easily detected through the currents from the conjugate by adjusting the pulse potential frequency in square-wave voltammetry. By using the present strategy, we succeeded in accurately detecting various naturally occurring single-nucleotide polymorphisms.
Original language | English |
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Pages (from-to) | 4822-4828 |
Number of pages | 7 |
Journal | Chemistry - A European Journal |
Volume | 15 |
Issue number | 19 |
DOIs | |
State | Published - 2009/05/04 |
Keywords
- Bending elasticity
- DNA
- Electrochemistry
- Single nucleotide polymorphisms
- Voltammetry
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Organic Chemistry