TY - JOUR
T1 - Cytokeratin-positive fibroblastic reticular cell tumor with follicular dendritic cell features
T2 - A case report and review of the literature
AU - Goto, Naoe
AU - Tsurumi, Hisashi
AU - Takami, Tsuyoshi
AU - Futamura, Manabu
AU - Morimitsu, Kasumi
AU - Takata, Katsuyoshi
AU - Sato, Yasuharu
AU - Yoshino, Tadashi
AU - Adachi, Seiji
AU - Saito, Koshiro
AU - Yamakawa, Mitsunori
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.
PY - 2015/3/30
Y1 - 2015/3/30
N2 - Fibroblastic reticular cell (FRC) neoplasms, which are one of the histiocyte tumor types, are very rare. Here we report a cytokeratin (CK)-positive FRC neoplasm having features of follicular dendritic cells in a 54-year-old woman with right axillary lymph node swelling. The resected lymph node showed multiple nodular aggregations simulating and replacing normal follicles. The tumor cells had a uniform, large and oval to polygonal shape, abundant cytoplasm, and various sizes of nuclei with central eosinophilic nucleoli and coarse nuclear chromatin. They were positive for CK AE1/AE3+CAM5.2, CK7, tenascin C, l-caldesomone, and CD21, weakly positive for S100, and negative for CD1a. Ultrastructurally, the tumor cells had long interdigitating microvillus-like cell processes and oval to elongated vesicular nuclei. In addition, the intercellular spaces contained accumulations of collagen, and some tumor cells had desmosomal-like junctions. These findings suggest that the present case is a CK-positive FRC tumor with follicular dendritic cell features.
AB - Fibroblastic reticular cell (FRC) neoplasms, which are one of the histiocyte tumor types, are very rare. Here we report a cytokeratin (CK)-positive FRC neoplasm having features of follicular dendritic cells in a 54-year-old woman with right axillary lymph node swelling. The resected lymph node showed multiple nodular aggregations simulating and replacing normal follicles. The tumor cells had a uniform, large and oval to polygonal shape, abundant cytoplasm, and various sizes of nuclei with central eosinophilic nucleoli and coarse nuclear chromatin. They were positive for CK AE1/AE3+CAM5.2, CK7, tenascin C, l-caldesomone, and CD21, weakly positive for S100, and negative for CD1a. Ultrastructurally, the tumor cells had long interdigitating microvillus-like cell processes and oval to elongated vesicular nuclei. In addition, the intercellular spaces contained accumulations of collagen, and some tumor cells had desmosomal-like junctions. These findings suggest that the present case is a CK-positive FRC tumor with follicular dendritic cell features.
KW - cytokeratin-positive FRC tumors
KW - fibroblastic reticular cell tumor
KW - FRC neoplasm
UR - http://www.scopus.com/inward/record.url?scp=84925860909&partnerID=8YFLogxK
U2 - 10.1097/PAS.0000000000000362
DO - 10.1097/PAS.0000000000000362
M3 - 総説
C2 - 25768257
AN - SCOPUS:84925860909
SN - 0147-5185
VL - 39
SP - 573
EP - 580
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 4
ER -