Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

Firoj Ahmed; Kazufumi Toume; Takashi Ohtsuki; Mahmudur Rahman; Samir Kumar Sadhu; Masami Ishibashi

doi:10.1002/ptr.3219

Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

Firoj Ahmed, Kazufumi Toume, Takashi Ohtsuki, Mahmudur Rahman, Samir Kumar Sadhu, Masami Ishibashi^*

^*Corresponding author for this work

Department of Medicinal Resources Management, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.

Original language	English
Pages (from-to)	147-150
Number of pages	4
Journal	Phytotherapy Research
Volume	25
Issue number	1
DOIs	https://doi.org/10.1002/ptr.3219
State	Published - 2011/01

Keywords

AGS cell lines
Malvaceae
Sida acuta
TRAIL-induced apoptosis
cryptolepine

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1002/ptr.3219

Cite this

@article{8a3e386290c54fd580467d485bfc9bef,

title = "Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis",

abstract = "Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.",

keywords = "AGS cell lines, Malvaceae, Sida acuta, TRAIL-induced apoptosis, cryptolepine",

author = "Firoj Ahmed and Kazufumi Toume and Takashi Ohtsuki and Mahmudur Rahman and Sadhu, {Samir Kumar} and Masami Ishibashi",

year = "2011",

month = jan,

doi = "10.1002/ptr.3219",

language = "英語",

volume = "25",

pages = "147--150",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

AU - Ahmed, Firoj

AU - Toume, Kazufumi

AU - Ohtsuki, Takashi

AU - Rahman, Mahmudur

AU - Sadhu, Samir Kumar

AU - Ishibashi, Masami

PY - 2011/1

Y1 - 2011/1

N2 - Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.

AB - Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.

KW - AGS cell lines

KW - Malvaceae

KW - Sida acuta

KW - TRAIL-induced apoptosis

KW - cryptolepine

UR - http://www.scopus.com/inward/record.url?scp=78650660594&partnerID=8YFLogxK

U2 - 10.1002/ptr.3219

DO - 10.1002/ptr.3219

M3 - 学術論文

C2 - 20623717

AN - SCOPUS:78650660594

SN - 0951-418X

VL - 25

SP - 147

EP - 150

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 1

ER -

Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this