Continuous-Flow Suzuki-Miyaura and Mizoroki-Heck Reactions under Microwave Heating Conditions

Yasunari Monguchi; Tomohiro Ichikawa; Tsuyoshi Yamada; Yoshinari Sawama; Hironao Sajiki

doi:10.1002/tcr.201800063

Continuous-Flow Suzuki-Miyaura and Mizoroki-Heck Reactions under Microwave Heating Conditions

Yasunari Monguchi^*, Tomohiro Ichikawa, Tsuyoshi Yamada, Yoshinari Sawama, Hironao Sajiki

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Microwave-assisted continuous-flow reactions have attracted significant interest from synthetic organic chemists, especially process chemists from practical points of view, due to a less complicated shift to large-scale synthesis based on simple and continuous access to products with low energy requirements. In this personal account, we focused on the Suzuki-Miyaura and Mizoroki-Heck reactions, both of which are significantly important cross-coupling reactions for the synthesis of various functional materials. Microwave power is effective for heating. Typical homogeneous palladium catalysts, such as PdCl₂(PPh₃)₂, Pd(PPh₃)₄, and Pd(OAc)₂, as well as heterogeneous palladium catalysts, such as Pd-film, Pd/Al₂O₃, Pd/SiO₂, and Pd supported on polymers, can be used for these reactions.

Original language	English
Pages (from-to)	3-14
Number of pages	12
Journal	Chemical Record
Volume	19
Issue number	1
DOIs	https://doi.org/10.1002/tcr.201800063
State	Published - 2019/01

Keywords

Cross-coupling
Flow reaction
Heterogeneous catalysis
Homogeneous catalysis
Microwave chemistry

ASJC Scopus subject areas

General Chemistry
Biochemistry
General Chemical Engineering
Materials Chemistry

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10.1002/tcr.201800063

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title = "Continuous-Flow Suzuki-Miyaura and Mizoroki-Heck Reactions under Microwave Heating Conditions",

abstract = "Microwave-assisted continuous-flow reactions have attracted significant interest from synthetic organic chemists, especially process chemists from practical points of view, due to a less complicated shift to large-scale synthesis based on simple and continuous access to products with low energy requirements. In this personal account, we focused on the Suzuki-Miyaura and Mizoroki-Heck reactions, both of which are significantly important cross-coupling reactions for the synthesis of various functional materials. Microwave power is effective for heating. Typical homogeneous palladium catalysts, such as PdCl2(PPh3)2, Pd(PPh3)4, and Pd(OAc)2, as well as heterogeneous palladium catalysts, such as Pd-film, Pd/Al2O3, Pd/SiO2, and Pd supported on polymers, can be used for these reactions.",

keywords = "Cross-coupling, Flow reaction, Heterogeneous catalysis, Homogeneous catalysis, Microwave chemistry",

author = "Yasunari Monguchi and Tomohiro Ichikawa and Tsuyoshi Yamada and Yoshinari Sawama and Hironao Sajiki",

note = "Publisher Copyright: {\textcopyright} 2019 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

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doi = "10.1002/tcr.201800063",

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AU - Monguchi, Yasunari

AU - Ichikawa, Tomohiro

AU - Yamada, Tsuyoshi

AU - Sawama, Yoshinari

AU - Sajiki, Hironao

PY - 2019/1

Y1 - 2019/1

N2 - Microwave-assisted continuous-flow reactions have attracted significant interest from synthetic organic chemists, especially process chemists from practical points of view, due to a less complicated shift to large-scale synthesis based on simple and continuous access to products with low energy requirements. In this personal account, we focused on the Suzuki-Miyaura and Mizoroki-Heck reactions, both of which are significantly important cross-coupling reactions for the synthesis of various functional materials. Microwave power is effective for heating. Typical homogeneous palladium catalysts, such as PdCl2(PPh3)2, Pd(PPh3)4, and Pd(OAc)2, as well as heterogeneous palladium catalysts, such as Pd-film, Pd/Al2O3, Pd/SiO2, and Pd supported on polymers, can be used for these reactions.

AB - Microwave-assisted continuous-flow reactions have attracted significant interest from synthetic organic chemists, especially process chemists from practical points of view, due to a less complicated shift to large-scale synthesis based on simple and continuous access to products with low energy requirements. In this personal account, we focused on the Suzuki-Miyaura and Mizoroki-Heck reactions, both of which are significantly important cross-coupling reactions for the synthesis of various functional materials. Microwave power is effective for heating. Typical homogeneous palladium catalysts, such as PdCl2(PPh3)2, Pd(PPh3)4, and Pd(OAc)2, as well as heterogeneous palladium catalysts, such as Pd-film, Pd/Al2O3, Pd/SiO2, and Pd supported on polymers, can be used for these reactions.

KW - Cross-coupling

KW - Flow reaction

KW - Heterogeneous catalysis

KW - Homogeneous catalysis

KW - Microwave chemistry

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Continuous-Flow Suzuki-Miyaura and Mizoroki-Heck Reactions under Microwave Heating Conditions

Abstract

Keywords

ASJC Scopus subject areas

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