Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

Tomohiro Minakawa; Kazufumi Toume; Firoj Ahmed; Samir Kumar Sadhu; Takashi Ohtsuki; Midori A. Arai; Masami Ishibashi

doi:10.1248/cpb.58.1549

Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

Tomohiro Minakawa, Kazufumi Toume, Firoj Ahmed, Samir Kumar Sadhu, Takashi Ohtsuki, Midori A. Arai, Masami Ishibashi^*

^*Corresponding author for this work

Department of Medicinal Resources Management, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

Original language	English
Pages (from-to)	1549-1551
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	58
Issue number	11
DOIs	https://doi.org/10.1248/cpb.58.1549
State	Published - 2010/11

Keywords

Flavanone
Pongamia pinnata
Screening

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.58.1549

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title = "Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance",

abstract = "In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.",

keywords = "Flavanone, Pongamia pinnata, Screening",

author = "Tomohiro Minakawa and Kazufumi Toume and Firoj Ahmed and Sadhu, {Samir Kumar} and Takashi Ohtsuki and Arai, {Midori A.} and Masami Ishibashi",

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doi = "10.1248/cpb.58.1549",

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T1 - Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

AU - Minakawa, Tomohiro

AU - Toume, Kazufumi

AU - Ahmed, Firoj

AU - Sadhu, Samir Kumar

AU - Ohtsuki, Takashi

AU - Arai, Midori A.

AU - Ishibashi, Masami

PY - 2010/11

Y1 - 2010/11

N2 - In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

AB - In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

KW - Flavanone

KW - Pongamia pinnata

KW - Screening

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AN - SCOPUS:78049476977

SN - 0009-2363

VL - 58

SP - 1549

EP - 1551

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 11

ER -

Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

Abstract

Keywords

ASJC Scopus subject areas

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