Concise preparation and biological evaluations of 9-cis-retinoic acid analogues having an aromatic ring

Takashi Okitsu; Kinya Iwatsuka; Kimie Nakagawa; Toshio Okano; Akimori Wada

doi:10.3987/COM-20-S(K)8

Concise preparation and biological evaluations of 9-cis-retinoic acid analogues having an aromatic ring

Takashi Okitsu^*, Kinya Iwatsuka, Kimie Nakagawa, Toshio Okano, Akimori Wada^*

^*Corresponding author for this work

Synthetic and Biomolecular Organic Chemistry

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A series of 9-cis-retinoic acid analogues having an aromatic ring were prepared in only two steps, and were evaluated for transcriptional activities with retinoic acid response element (RARE) and retinoid X response element (RXRE). Among them, compound 6c, bearing a 2-naphthyl substituent, exhibited the highest transcriptional activity with RXR selectivity.

Original language	English
Journal	Heterocycles
Volume	103
Issue number	1
DOIs	https://doi.org/10.3987/COM-20-S(K)8
State	Published - 2021

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-20-S(K)8

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@article{78ef63fcfc49486d9460cd3c22af43de,

title = "Concise preparation and biological evaluations of 9-cis-retinoic acid analogues having an aromatic ring",

abstract = "A series of 9-cis-retinoic acid analogues having an aromatic ring were prepared in only two steps, and were evaluated for transcriptional activities with retinoic acid response element (RARE) and retinoid X response element (RXRE). Among them, compound 6c, bearing a 2-naphthyl substituent, exhibited the highest transcriptional activity with RXR selectivity.",

author = "Takashi Okitsu and Kinya Iwatsuka and Kimie Nakagawa and Toshio Okano and Akimori Wada",

year = "2021",

doi = "10.3987/COM-20-S(K)8",

language = "英語",

volume = "103",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "1",

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T1 - Concise preparation and biological evaluations of 9-cis-retinoic acid analogues having an aromatic ring

AU - Okitsu, Takashi

AU - Iwatsuka, Kinya

AU - Nakagawa, Kimie

AU - Okano, Toshio

AU - Wada, Akimori

PY - 2021

Y1 - 2021

N2 - A series of 9-cis-retinoic acid analogues having an aromatic ring were prepared in only two steps, and were evaluated for transcriptional activities with retinoic acid response element (RARE) and retinoid X response element (RXRE). Among them, compound 6c, bearing a 2-naphthyl substituent, exhibited the highest transcriptional activity with RXR selectivity.

AB - A series of 9-cis-retinoic acid analogues having an aromatic ring were prepared in only two steps, and were evaluated for transcriptional activities with retinoic acid response element (RARE) and retinoid X response element (RXRE). Among them, compound 6c, bearing a 2-naphthyl substituent, exhibited the highest transcriptional activity with RXR selectivity.

UR - http://www.scopus.com/inward/record.url?scp=85104974037&partnerID=8YFLogxK

U2 - 10.3987/COM-20-S(K)8

DO - 10.3987/COM-20-S(K)8

M3 - 学術論文

AN - SCOPUS:85104974037

SN - 0385-5414

VL - 103

JO - Heterocycles

JF - Heterocycles

IS - 1

ER -

Concise preparation and biological evaluations of 9-cis-retinoic acid analogues having an aromatic ring

Abstract

ASJC Scopus subject areas

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