Comparison of intravenous versus intraperitoneal administration of oncolytic herpes simplex virus 1 for peritoneal carcinomatosis in mice

Keyphrases

• Intravenous Administration 100%
• Intraperitoneal Administration 100%
• Peritoneal Carcinomatosis 100%
• Oncolytic Herpes Simplex Virus (oHSV) 100%
• Biodistribution 57%
• Peritoneal Metastasis 42%
• Herpes Simplex Virus Type 1 (HSV-1) 42%
• Lethal Dose 50 (LD50) 42%
• Tumor 28%
• Lung 28%
• Kidney 28%
• Virus 28%
• Tumor Burden 28%
• Liver 14%
• Liver Metastasis 14%
• Immunodeficient Mice 14%
• Spleen 14%
• Small Intestine 14%
• Survival Benefit 14%
• Colorectal Carcinoma 14%
• Median Survival 14%
• Colon Adenocarcinoma 14%
• Specific Sequences 14%
• Peritoneal Tumor 14%
• Intravenous Route 14%
• PCR Amplification 14%
• Every Other Day 14%
• Animal Survival 14%
• Reduced Frequency 14%
• Intraperitoneal Route 14%
• Oncolytic 14%
• Plaque-forming Units 14%
• Portal Venous 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Human Alphaherpesvirus 1 100%
• Oncolytic Herpes Virus 100%
• Carcinomatous Peritonitis 100%
• Neoplasm 80%
• Biodistribution 80%
• Peritoneum Metastasis 60%
• Liver Metastasis 20%
• Colorectal Carcinoma 20%
• Colon Carcinoma 20%
• Intravenous Route 20%
• Peritoneum Tumor 20%