Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes

Masakado Matsumoto; Kenji Sakae; Shinnosuke Hashikawa; Keizo Torii; Tadao Hasegawa; Toshinobu Horii; Miyoko Endo; Rumi Okuno; Shoko Murayama; Kyoko Hirasawa; Rieko Suzuki; Junko Isobe; Daisuke Tanaka; Chihiro Katsukawa; Aki Tamaru; Masaaki Tomita; Kikuyo Ogata; Tadayoshi Ikebe; Haruo Watanabe; Michio Ohta; H. Saito; K. Otani; M. Oguro; J. Fujisaki; K. Sugama; S. Hosorogi; M. Sakaki; Y. Kasama; H. Tanaka; C. Sunahara; T. Shimizu; S. Moroishi; Y. Abe; J. Kudaka

doi:10.1111/j.1348-0421.2005.tb03684.x

Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes

Masakado Matsumoto^*, Kenji Sakae, Shinnosuke Hashikawa, Keizo Torii, Tadao Hasegawa, Toshinobu Horii, Miyoko Endo, Rumi Okuno, Shoko Murayama, Kyoko Hirasawa, Rieko Suzuki, Junko Isobe, Daisuke Tanaka, Chihiro Katsukawa, Aki Tamaru, Masaaki Tomita, Kikuyo Ogata, Tadayoshi Ikebe, Haruo Watanabe, Michio OhtaH. Saito, K. Otani, M. Oguro, J. Fujisaki, K. Sugama, S. Hosorogi, M. Sakaki, Y. Kasama, H. Tanaka, C. Sunahara, T. Shimizu, S. Moroishi, Y. Abe, J. Kudaka

^*Corresponding author for this work

Program of Natural and Environmental Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

DNase B is a major nuclease and a possible virulence factor in Streptococcus pyogenes. The allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes. Of the 15 alleles identified, 11 alleles carried only synonymous nucleotide substitutions. On the other hand, 4 alleles had a non-synonymous substitution other than synonymous substitutions, resulting in the substitution of a single amino acid. The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles.

Original language	English
Pages (from-to)	925-929
Number of pages	5
Journal	Microbiology and Immunology
Volume	49
Issue number	10
DOIs	https://doi.org/10.1111/j.1348-0421.2005.tb03684.x
State	Published - 2005

Keywords

SdaB gene
Streptococcus pyogenes
emm genotype

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/j.1348-0421.2005.tb03684.x

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Matsumoto, M., Sakae, K., Hashikawa, S., Torii, K., Hasegawa, T., Horii, T., Endo, M., Okuno, R., Murayama, S., Hirasawa, K., Suzuki, R., Isobe, J., Tanaka, D., Katsukawa, C., Tamaru, A., Tomita, M., Ogata, K., Ikebe, T., Watanabe, H., ... Kudaka, J. (2005). Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes. Microbiology and Immunology, 49(10), 925-929. https://doi.org/10.1111/j.1348-0421.2005.tb03684.x

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title = "Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes",

abstract = "DNase B is a major nuclease and a possible virulence factor in Streptococcus pyogenes. The allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes. Of the 15 alleles identified, 11 alleles carried only synonymous nucleotide substitutions. On the other hand, 4 alleles had a non-synonymous substitution other than synonymous substitutions, resulting in the substitution of a single amino acid. The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles.",

keywords = "SdaB gene, Streptococcus pyogenes, emm genotype",

author = "Masakado Matsumoto and Kenji Sakae and Shinnosuke Hashikawa and Keizo Torii and Tadao Hasegawa and Toshinobu Horii and Miyoko Endo and Rumi Okuno and Shoko Murayama and Kyoko Hirasawa and Rieko Suzuki and Junko Isobe and Daisuke Tanaka and Chihiro Katsukawa and Aki Tamaru and Masaaki Tomita and Kikuyo Ogata and Tadayoshi Ikebe and Haruo Watanabe and Michio Ohta and H. Saito and K. Otani and M. Oguro and J. Fujisaki and K. Sugama and S. Hosorogi and M. Sakaki and Y. Kasama and H. Tanaka and C. Sunahara and T. Shimizu and S. Moroishi and Y. Abe and J. Kudaka",

year = "2005",

doi = "10.1111/j.1348-0421.2005.tb03684.x",

language = "英語",

volume = "49",

pages = "925--929",

journal = "Microbiology and Immunology",

issn = "0385-5600",

publisher = "Wiley-Blackwell",

number = "10",

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Matsumoto, M, Sakae, K, Hashikawa, S, Torii, K, Hasegawa, T, Horii, T, Endo, M, Okuno, R, Murayama, S, Hirasawa, K, Suzuki, R, Isobe, J, Tanaka, D, Katsukawa, C, Tamaru, A, Tomita, M, Ogata, K, Ikebe, T, Watanabe, H, Ohta, M, Saito, H, Otani, K, Oguro, M, Fujisaki, J, Sugama, K, Hosorogi, S, Sakaki, M, Kasama, Y, Tanaka, H, Sunahara, C, Shimizu, T, Moroishi, S, Abe, Y & Kudaka, J 2005, 'Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes', Microbiology and Immunology, vol. 49, no. 10, pp. 925-929. https://doi.org/10.1111/j.1348-0421.2005.tb03684.x

TY - JOUR

T1 - Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes

AU - Matsumoto, Masakado

AU - Sakae, Kenji

AU - Hashikawa, Shinnosuke

AU - Torii, Keizo

AU - Hasegawa, Tadao

AU - Horii, Toshinobu

AU - Endo, Miyoko

AU - Okuno, Rumi

AU - Murayama, Shoko

AU - Hirasawa, Kyoko

AU - Suzuki, Rieko

AU - Isobe, Junko

AU - Tanaka, Daisuke

AU - Katsukawa, Chihiro

AU - Tamaru, Aki

AU - Tomita, Masaaki

AU - Ogata, Kikuyo

AU - Ikebe, Tadayoshi

AU - Watanabe, Haruo

AU - Ohta, Michio

AU - Saito, H.

AU - Otani, K.

AU - Oguro, M.

AU - Fujisaki, J.

AU - Sugama, K.

AU - Hosorogi, S.

AU - Sakaki, M.

AU - Kasama, Y.

AU - Tanaka, H.

AU - Sunahara, C.

AU - Shimizu, T.

AU - Moroishi, S.

AU - Abe, Y.

AU - Kudaka, J.

PY - 2005

Y1 - 2005

N2 - DNase B is a major nuclease and a possible virulence factor in Streptococcus pyogenes. The allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes. Of the 15 alleles identified, 11 alleles carried only synonymous nucleotide substitutions. On the other hand, 4 alleles had a non-synonymous substitution other than synonymous substitutions, resulting in the substitution of a single amino acid. The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles.

AB - DNase B is a major nuclease and a possible virulence factor in Streptococcus pyogenes. The allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes. Of the 15 alleles identified, 11 alleles carried only synonymous nucleotide substitutions. On the other hand, 4 alleles had a non-synonymous substitution other than synonymous substitutions, resulting in the substitution of a single amino acid. The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles.

KW - SdaB gene

KW - Streptococcus pyogenes

KW - emm genotype

UR - http://www.scopus.com/inward/record.url?scp=27544491279&partnerID=8YFLogxK

U2 - 10.1111/j.1348-0421.2005.tb03684.x

DO - 10.1111/j.1348-0421.2005.tb03684.x

M3 - 学術論文

C2 - 16237270

AN - SCOPUS:27544491279

SN - 0385-5600

VL - 49

SP - 925

EP - 929

JO - Microbiology and Immunology

JF - Microbiology and Immunology

IS - 10

ER -

Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes

Abstract

Keywords

ASJC Scopus subject areas

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