Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus

Shun Tanimura, Yuichiro Fujieda*, Michihiro Kono, Yuhei Shibata, Ryo Hisada, Eri Sugawara, Hiroyuki Nakamura, Kazumasa Ohmura, Sanae Shimamura, Asako Mitani, Haruki Shida, Toshiyuki Watanabe, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Chikara Shimizu, Tatsuya Atsumi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objectives: Presepsin (PSEP: soluble CD14 subtype) is produced from bacteria-stimulated monocytes or neutrophils, thus recognized as a biomarker of sepsis. Aberrant functions in monocyte or neutrophils are increasingly recognized in systemic lupus erythematosus (SLE). We investigated whether plasma PSEP reflects disease activity in patients with SLE. Methods: This retrospective study comprised 35 patients with SLE and 72 with non-SLE autoimmune diseases who visited our facility during the period from August 2012 to September 2015. Plasma PSEP levels and laboratory data were compared between SLE and non-SLE. Clinical markers of SLE disease activity, including SLE disease activity index 2000 (SLEDAI-2K), serum complement concentrations and serum anti-ds-DNA antibodies were assessed in correlation with plasma PSEP levels. Results: Plasma PSEP levels in SLE were higher than those in non-SLE. This phenomenon holds true when comparing SLE and non-SLE patients in the absence of infection (p =.0008). Plasma PSEP levels in SLE patients negatively correlated with C3 (r = –0.4454, p =.0430), CH50 (r = –0.4502, p =.0406) and positively with SLEDAI-2K (r = 0.4801, p =.0237). Conclusion: Elevated plasma PSEP levels were correlated with disease activity of SLE, suggesting inappropriate monocyte or neutrophil activation in the pathophysiology of SLE exacerbation.

Original languageEnglish
Pages (from-to)865-871
Number of pages7
JournalModern Rheumatology
Volume28
Issue number5
DOIs
StatePublished - 2018/09/03

Keywords

  • CD14
  • monocyte
  • presepsin (PSEP)
  • soluble CD14-ST
  • systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • General Medicine

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