Clinical investigation of 38 cases of oral mucosal melanoma: A multicentre retrospective analysis in Japan

Shin Ichi Yamada; Hiroshi Kurita; Takahiro Kamata; Tadaaki Kirita; Michihiro Ueda; Tetsuro Yamashita; Yoshihide Ota; Mitsunobu Otsuru; Nobuhiro Yamakawa; Masaya Okura; Tomonao Aikawa; Souichi Yanamoto; Masahiro Umeda

doi:10.1111/ajd.12603

Clinical investigation of 38 cases of oral mucosal melanoma: A multicentre retrospective analysis in Japan

Shin Ichi Yamada^*, Hiroshi Kurita, Takahiro Kamata, Tadaaki Kirita, Michihiro Ueda, Tetsuro Yamashita, Yoshihide Ota, Mitsunobu Otsuru, Nobuhiro Yamakawa, Masaya Okura, Tomonao Aikawa, Souichi Yanamoto, Masahiro Umeda

^*Corresponding author for this work

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background/Objectives: The aim of the present study was to investigate treatment modalities and outcomes in oral mucosal melanoma. Methods: The clinical and pathological data of 38 consecutive patients with oral mucosal melanoma were retrospectively analyzed. Patients' characteristics were analyzed and overall survival (OS) rates were calculated. Results: Sixteen patients had stage III (42%), 19 IVA (50%), and three had stage IVC (8%) disease. Among the therapeutic approaches used, 31 patients (82%) received radical therapy (surgery +/− chemotherapy). The 5-year OS rate was 40%. Five-year OS rates according to the clinical stage were 71% for stage III, 24% for stage IVA, and 0% for stage IVC. Five-year OS rates according to therapeutic approaches were 52% in the radical therapy group and 0% in the palliative therapy and best supportive care groups. Conclusions: The results of this multicentre retrospective analysis of patients with oral mucosal melanoma suggest that radical therapy based on surgical treatments with complete surgical excision with clear margins leads to a better prognosis.

Original language	English
Pages (from-to)	e223-e227
Journal	Australasian Journal of Dermatology
Volume	58
Issue number	4
DOIs	https://doi.org/10.1111/ajd.12603
State	Published - 2017/11

Keywords

mucosal melanoma
oral cavity
prognosis
survival analysis
treatment outcome

ASJC Scopus subject areas

Dermatology

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10.1111/ajd.12603

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@article{cf9ef30bdad64f589d5c82b843b67d4a,

title = "Clinical investigation of 38 cases of oral mucosal melanoma: A multicentre retrospective analysis in Japan",

abstract = "Background/Objectives: The aim of the present study was to investigate treatment modalities and outcomes in oral mucosal melanoma. Methods: The clinical and pathological data of 38 consecutive patients with oral mucosal melanoma were retrospectively analyzed. Patients' characteristics were analyzed and overall survival (OS) rates were calculated. Results: Sixteen patients had stage III (42%), 19 IVA (50%), and three had stage IVC (8%) disease. Among the therapeutic approaches used, 31 patients (82%) received radical therapy (surgery +/− chemotherapy). The 5-year OS rate was 40%. Five-year OS rates according to the clinical stage were 71% for stage III, 24% for stage IVA, and 0% for stage IVC. Five-year OS rates according to therapeutic approaches were 52% in the radical therapy group and 0% in the palliative therapy and best supportive care groups. Conclusions: The results of this multicentre retrospective analysis of patients with oral mucosal melanoma suggest that radical therapy based on surgical treatments with complete surgical excision with clear margins leads to a better prognosis.",

keywords = "mucosal melanoma, oral cavity, prognosis, survival analysis, treatment outcome",

author = "Yamada, {Shin Ichi} and Hiroshi Kurita and Takahiro Kamata and Tadaaki Kirita and Michihiro Ueda and Tetsuro Yamashita and Yoshihide Ota and Mitsunobu Otsuru and Nobuhiro Yamakawa and Masaya Okura and Tomonao Aikawa and Souichi Yanamoto and Masahiro Umeda",

note = "Publisher Copyright: {\textcopyright} 2017 The Australasian College of Dermatologists",

year = "2017",

month = nov,

doi = "10.1111/ajd.12603",

language = "英語",

volume = "58",

pages = "e223--e227",

journal = "Australasian Journal of Dermatology",

issn = "0004-8380",

publisher = "John Wiley and Sons Inc.",

number = "4",

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TY - JOUR

T1 - Clinical investigation of 38 cases of oral mucosal melanoma

T2 - A multicentre retrospective analysis in Japan

AU - Yamada, Shin Ichi

AU - Kurita, Hiroshi

AU - Kamata, Takahiro

AU - Kirita, Tadaaki

AU - Ueda, Michihiro

AU - Yamashita, Tetsuro

AU - Ota, Yoshihide

AU - Otsuru, Mitsunobu

AU - Yamakawa, Nobuhiro

AU - Okura, Masaya

AU - Aikawa, Tomonao

AU - Yanamoto, Souichi

AU - Umeda, Masahiro

PY - 2017/11

Y1 - 2017/11

N2 - Background/Objectives: The aim of the present study was to investigate treatment modalities and outcomes in oral mucosal melanoma. Methods: The clinical and pathological data of 38 consecutive patients with oral mucosal melanoma were retrospectively analyzed. Patients' characteristics were analyzed and overall survival (OS) rates were calculated. Results: Sixteen patients had stage III (42%), 19 IVA (50%), and three had stage IVC (8%) disease. Among the therapeutic approaches used, 31 patients (82%) received radical therapy (surgery +/− chemotherapy). The 5-year OS rate was 40%. Five-year OS rates according to the clinical stage were 71% for stage III, 24% for stage IVA, and 0% for stage IVC. Five-year OS rates according to therapeutic approaches were 52% in the radical therapy group and 0% in the palliative therapy and best supportive care groups. Conclusions: The results of this multicentre retrospective analysis of patients with oral mucosal melanoma suggest that radical therapy based on surgical treatments with complete surgical excision with clear margins leads to a better prognosis.

AB - Background/Objectives: The aim of the present study was to investigate treatment modalities and outcomes in oral mucosal melanoma. Methods: The clinical and pathological data of 38 consecutive patients with oral mucosal melanoma were retrospectively analyzed. Patients' characteristics were analyzed and overall survival (OS) rates were calculated. Results: Sixteen patients had stage III (42%), 19 IVA (50%), and three had stage IVC (8%) disease. Among the therapeutic approaches used, 31 patients (82%) received radical therapy (surgery +/− chemotherapy). The 5-year OS rate was 40%. Five-year OS rates according to the clinical stage were 71% for stage III, 24% for stage IVA, and 0% for stage IVC. Five-year OS rates according to therapeutic approaches were 52% in the radical therapy group and 0% in the palliative therapy and best supportive care groups. Conclusions: The results of this multicentre retrospective analysis of patients with oral mucosal melanoma suggest that radical therapy based on surgical treatments with complete surgical excision with clear margins leads to a better prognosis.

KW - mucosal melanoma

KW - oral cavity

KW - prognosis

KW - survival analysis

KW - treatment outcome

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U2 - 10.1111/ajd.12603

DO - 10.1111/ajd.12603

M3 - 学術論文

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AN - SCOPUS:85034650733

SN - 0004-8380

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SP - e223-e227

JO - Australasian Journal of Dermatology

JF - Australasian Journal of Dermatology

IS - 4

ER -

Clinical investigation of 38 cases of oral mucosal melanoma: A multicentre retrospective analysis in Japan

Abstract

Keywords

ASJC Scopus subject areas

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