@article{ec86c77eec62416ba308bc534df9b0dd,
title = "Chemical Sensing with Chemically Modified Electrodes that Mimic Gating at Biomembranes Incorporating Ion-Channel Receptors",
abstract = "Selective binding of electroinactive analytes to electrodes that are chemically modified with receptors can be used to control heterogeneous redox reactions of electroactive species. The latter are in this context often called markers because their use allows the indirect determination of the electroinactive analytes with the inherent possibility for chemical signal amplification. Two different approaches can be distinguished. To structurally mimic natural ion-channel proteins, electrodes are modified with artificial receptors having intramolecular channels that can be blocked by formation of inclusion complexes with the analyte. In more abstract analogy to the working principle of ion-channel proteins, binding of usually charged analytes to receptors without intramolecular channels is used to control redox reactions of the marker species on the basis of electrostatic interactions, and, occasionally, of steric repulsion. The versatility and general characteristics of this type of chemically gated sensors are discussed, and specific examples from recent studies are presented.",
keywords = "Calixarene, Chemically moditied electrode, Cyclodextrin, Hydrogen bond, Ion channel, Langmuir-Blodgett membrane, Nucleotide, Phosphate, Self-assembled monolayer",
author = "Philippe B{\"u}hlmann and Hiroshi Aoki and Xiao, {Kang Ping} and Shigeru Amemiya and Koji Tohda and Yoshio Umezawa",
note = "Funding Information: for the wwPDB consortium comes from multiple sources. The RCSB Protein Data Bank is funded jointly by the National Science Foundation, National Institute of General Medical Sciences, National Cancer Institute and Department of Energy. The Protein Data Bank in Europe is supported by the European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust, Biotechnology and Biological Sciences Research Council, and the European Union. The Protein Data Bank Japan is supported by the Database Integration Coordination Program from the National Bioscience Database Centre (NBDC)-JST (Japan Science and Technology Agency) and the joint usage program of Institute for Protein Research, Osaka University. The BioMagResBank is supported by the US National Institutes of Health. Funding Information: Funding for the wwPDB consortium comes from multiple sources. The RCSB Protein Data Bank is funded jointly by the National Science Foundation, National Institute of General Medical Sciences, National Cancer Institute and Department of Energy. The Protein Data Bank in Europe is supported by the European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust, Biotechnology and Biological Sciences Research Council, and the European Union. The Protein Data Bank Japan is supported by the Database Integration Coordination Program from the National Bioscience Database Centre (NBDC)-JST (Japan Science and Technology Agency) and the joint usage program of Institute for Protein Research, Osaka University. The BioMagResBank is supported by the US National Institutes of Health.",
year = "1998",
month = dec,
doi = "10.1002/(SICI)1521-4109(199811)10:17<1149::AID-ELAN1149>3.0.CO;2-N",
language = "英語",
volume = "10",
pages = "1149--1158",
journal = "Electroanalysis",
issn = "1040-0397",
publisher = "Wiley-VCH Verlag",
number = "17",
}