Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line

Feng Li; Suresh Awale; Hongyan Zhang; Yasuhiro Tezuka; Hiroyasu Esumi; Shigetoshi Kadota

doi:10.1021/np9002433

Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line

Feng Li, Suresh Awale, Hongyan Zhang, Yasuhiro Tezuka, Hiroyasu Esumi, Shigetoshi Kadota^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC₅₀ value of 9.3 μg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC₅₀ 4.3 μM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.

Original language	English
Pages (from-to)	1283-1287
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	7
DOIs	https://doi.org/10.1021/np9002433
State	Published - 2009/07/24

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np9002433

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title = "Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line",

abstract = "A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC50 value of 9.3 μg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC50 4.3 μM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.",

author = "Feng Li and Suresh Awale and Hongyan Zhang and Yasuhiro Tezuka and Hiroyasu Esumi and Shigetoshi Kadota",

year = "2009",

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doi = "10.1021/np9002433",

language = "英語",

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journal = "Journal of Natural Products",

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AU - Li, Feng

AU - Awale, Suresh

AU - Zhang, Hongyan

AU - Tezuka, Yasuhiro

AU - Esumi, Hiroyasu

AU - Kadota, Shigetoshi

PY - 2009/7/24

Y1 - 2009/7/24

N2 - A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC50 value of 9.3 μg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC50 4.3 μM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.

AB - A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC50 value of 9.3 μg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC50 4.3 μM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.

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Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line

Abstract

ASJC Scopus subject areas

UN SDGs

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