Abstract
The 70% ethanolic extract of Artemisia vulgaris showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition with PC50 12.5 μg/mL. A phytochemical investigation of this extract yielded a new bicyclic [4:3:0] sesquiterpene named (+)-vulgaric acid (1), together with eight previously reported compounds. The structural elucidation of 1 was achieved by HRFABMS and NMR analysis. The absolute configuration of 1 was deduced by computational calculations of ECD data. All isolated compounds were tested for preferential cytotoxicity against PANC-1 cells, and apigenin (3) showed the strongest activity with PC50 30.7 μM.
Original language | English |
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Pages (from-to) | 4279-4285 |
Number of pages | 7 |
Journal | Natural Product Research |
Volume | 35 |
Issue number | 22 |
DOIs | |
State | Published - 2021 |
Keywords
- Artemisia vulgaris
- ECD calculation
- anti-austerity
- sesquiterpene
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Plant Science
- Organic Chemistry