Chemical constituents and absolute configuration of megastigmanes’ isolated from Sedum sarmentosum Bunge

Dinh Xuan Doan; Sijia Sun; Ashraf M. Omar; Dong Thuong Nguyen; Anh Le Tuan Hoang; Hironori Fujiwara; Kinzo Matsumoto; Hang Thi Nguyet Pham; Suresh Awale

doi:10.1080/14786419.2020.1834549

Chemical constituents and absolute configuration of megastigmanes’ isolated from Sedum sarmentosum Bunge

Dinh Xuan Doan, Sijia Sun, Ashraf M. Omar, Dong Thuong Nguyen, Anh Le Tuan Hoang, Hironori Fujiwara, Kinzo Matsumoto, Hang Thi Nguyet Pham, Suresh Awale^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Phytochemical investigation of a methanolic extract of Sedum sarmentosum collected from Vietnam resulted in the isolation of a new megastigmane glucoside, named sedumoside K (1), together with 17 previously reported compounds (2–18). Structural elucidation of the new compound was achieved by HRFABMS, NMR spectroscopic analysis, acid hydrolysis and quantum ECD calculations. The absolute configuration of compounds 2–6 has been revised. The major isolates were tested for cytotoxic activity against HeLa human cervical cancer cells, and all showed moderate activities.

Original language	English
Pages (from-to)	2341-2348
Number of pages	8
Journal	Natural Product Research
Volume	36
Issue number	9
DOIs	https://doi.org/10.1080/14786419.2020.1834549
State	Published - 2022

Keywords

ECD calculation
Megastigmane
Sedum sarmentosum
absolute configuration

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

Access to Document

10.1080/14786419.2020.1834549

Cite this

@article{10ac954521fc41aabf12a6cfaac864ec,

title = "Chemical constituents and absolute configuration of megastigmanes{\textquoteright} isolated from Sedum sarmentosum Bunge",

abstract = "Phytochemical investigation of a methanolic extract of Sedum sarmentosum collected from Vietnam resulted in the isolation of a new megastigmane glucoside, named sedumoside K (1), together with 17 previously reported compounds (2–18). Structural elucidation of the new compound was achieved by HRFABMS, NMR spectroscopic analysis, acid hydrolysis and quantum ECD calculations. The absolute configuration of compounds 2–6 has been revised. The major isolates were tested for cytotoxic activity against HeLa human cervical cancer cells, and all showed moderate activities.",

keywords = "ECD calculation, Megastigmane, Sedum sarmentosum, absolute configuration",

author = "Doan, {Dinh Xuan} and Sijia Sun and Omar, {Ashraf M.} and Nguyen, {Dong Thuong} and Hoang, {Anh Le Tuan} and Hironori Fujiwara and Kinzo Matsumoto and Pham, {Hang Thi Nguyet} and Suresh Awale",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2022",

doi = "10.1080/14786419.2020.1834549",

language = "英語",

volume = "36",

pages = "2341--2348",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor and Francis Ltd.",

number = "9",

}

TY - JOUR

T1 - Chemical constituents and absolute configuration of megastigmanes’ isolated from Sedum sarmentosum Bunge

AU - Doan, Dinh Xuan

AU - Sun, Sijia

AU - Omar, Ashraf M.

AU - Nguyen, Dong Thuong

AU - Hoang, Anh Le Tuan

AU - Fujiwara, Hironori

AU - Matsumoto, Kinzo

AU - Pham, Hang Thi Nguyet

AU - Awale, Suresh

PY - 2022

Y1 - 2022

N2 - Phytochemical investigation of a methanolic extract of Sedum sarmentosum collected from Vietnam resulted in the isolation of a new megastigmane glucoside, named sedumoside K (1), together with 17 previously reported compounds (2–18). Structural elucidation of the new compound was achieved by HRFABMS, NMR spectroscopic analysis, acid hydrolysis and quantum ECD calculations. The absolute configuration of compounds 2–6 has been revised. The major isolates were tested for cytotoxic activity against HeLa human cervical cancer cells, and all showed moderate activities.

AB - Phytochemical investigation of a methanolic extract of Sedum sarmentosum collected from Vietnam resulted in the isolation of a new megastigmane glucoside, named sedumoside K (1), together with 17 previously reported compounds (2–18). Structural elucidation of the new compound was achieved by HRFABMS, NMR spectroscopic analysis, acid hydrolysis and quantum ECD calculations. The absolute configuration of compounds 2–6 has been revised. The major isolates were tested for cytotoxic activity against HeLa human cervical cancer cells, and all showed moderate activities.

KW - ECD calculation

KW - Megastigmane

KW - Sedum sarmentosum

KW - absolute configuration

UR - http://www.scopus.com/inward/record.url?scp=85093092735&partnerID=8YFLogxK

U2 - 10.1080/14786419.2020.1834549

DO - 10.1080/14786419.2020.1834549

M3 - 学術論文

C2 - 33078638

AN - SCOPUS:85093092735

SN - 1478-6419

VL - 36

SP - 2341

EP - 2348

JO - Natural Product Research

JF - Natural Product Research

IS - 9

ER -

Chemical constituents and absolute configuration of megastigmanes’ isolated from Sedum sarmentosum Bunge

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this