Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

Kiyofumi Yamada; Atsumi Nitta; Tsuyoshi Saito; Jianguo Hu; Toshitaka Nabeshima

doi:10.1016/0304-3940(95)12161-7

Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

Kiyofumi Yamada, Atsumi Nitta, Tsuyoshi Saito, Jianguo Hu, Toshitaka Nabeshima^*

^*Corresponding author for this work

Pharmaceutical Therapy and Neuropharmacology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

Original language	English
Pages (from-to)	155-158
Number of pages	4
Journal	Neuroscience Letters
Volume	201
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(95)12161-7
State	Published - 1995/12/08

Keywords

Alzheimer's disease
Ciliary neurotrophic factor
Enzyme immunoassay
Memory
Trophic factor
β-amyloid

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(95)12161-7

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title = "Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein",

abstract = "We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.",

keywords = "Alzheimer's disease, Ciliary neurotrophic factor, Enzyme immunoassay, Memory, Trophic factor, β-amyloid",

author = "Kiyofumi Yamada and Atsumi Nitta and Tsuyoshi Saito and Jianguo Hu and Toshitaka Nabeshima",

note = "Funding Information: This study was supportedi,n part, by a grant (No. 007557009f)r om the Ministry of Education,S ciencea nd Culture of Japan, a grantf rom the Ministry of Health and Welfare Foundationfo r GerontologicaSl cienceR esearch (91A-2406), an SRF Grant for Biomedical Research,a grant from the Japan ResearchF oundationf or Clinical Pharmacologya, nd a grant from the Uehara Memorial Foundation.",

year = "1995",

month = dec,

day = "8",

doi = "10.1016/0304-3940(95)12161-7",

language = "英語",

volume = "201",

pages = "155--158",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

AU - Yamada, Kiyofumi

AU - Nitta, Atsumi

AU - Saito, Tsuyoshi

AU - Hu, Jianguo

AU - Nabeshima, Toshitaka

N1 - Funding Information: This study was supportedi,n part, by a grant (No. 007557009f)r om the Ministry of Education,S ciencea nd Culture of Japan, a grantf rom the Ministry of Health and Welfare Foundationfo r GerontologicaSl cienceR esearch (91A-2406), an SRF Grant for Biomedical Research,a grant from the Japan ResearchF oundationf or Clinical Pharmacologya, nd a grant from the Uehara Memorial Foundation.

PY - 1995/12/8

Y1 - 1995/12/8

N2 - We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

AB - We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

KW - Alzheimer's disease

KW - Ciliary neurotrophic factor

KW - Enzyme immunoassay

KW - Memory

KW - Trophic factor

KW - β-amyloid

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U2 - 10.1016/0304-3940(95)12161-7

DO - 10.1016/0304-3940(95)12161-7

M3 - 学術論文

C2 - 8848241

AN - SCOPUS:0028802698

SN - 0304-3940

VL - 201

SP - 155

EP - 158

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

Abstract

Keywords

ASJC Scopus subject areas

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