Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain

Tadasu Matsuoka; Tomiki Sumiyoshi; Masahiko Tsunoda; Ichiro Takasaki; Yoshiaki Tabuchi; Takashi Uehara; Hiroko Itoh; Michio Suzuki; Masayoshi Kurachi

doi:10.1007/s00702-010-0461-0

Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain

Tadasu Matsuoka, Tomiki Sumiyoshi^*, Masahiko Tsunoda, Ichiro Takasaki, Yoshiaki Tabuchi, Takashi Uehara, Hiroko Itoh, Michio Suzuki, Masayoshi Kurachi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.

Original language	English
Pages (from-to)	1265-1268
Number of pages	4
Journal	Journal of Neural Transmission
Volume	117
Issue number	11
DOIs	https://doi.org/10.1007/s00702-010-0461-0
State	Published - 2010/11

Keywords

Age
Brain
Development
Microarray
Myelination
Quantitative PCR
Rat
Schizophrenia

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00702-010-0461-0

Cite this

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title = "Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain",

abstract = "Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.",

keywords = "Age, Brain, Development, Microarray, Myelination, Quantitative PCR, Rat, Schizophrenia",

author = "Tadasu Matsuoka and Tomiki Sumiyoshi and Masahiko Tsunoda and Ichiro Takasaki and Yoshiaki Tabuchi and Takashi Uehara and Hiroko Itoh and Michio Suzuki and Masayoshi Kurachi",

year = "2010",

month = nov,

doi = "10.1007/s00702-010-0461-0",

language = "英語",

volume = "117",

pages = "1265--1268",

journal = "Journal of Neural Transmission",

issn = "0300-9564",

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number = "11",

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TY - JOUR

T1 - Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain

AU - Matsuoka, Tadasu

AU - Sumiyoshi, Tomiki

AU - Tsunoda, Masahiko

AU - Takasaki, Ichiro

AU - Tabuchi, Yoshiaki

AU - Uehara, Takashi

AU - Itoh, Hiroko

AU - Suzuki, Michio

AU - Kurachi, Masayoshi

PY - 2010/11

Y1 - 2010/11

N2 - Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.

AB - Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.

KW - Age

KW - Brain

KW - Development

KW - Microarray

KW - Myelination

KW - Quantitative PCR

KW - Rat

KW - Schizophrenia

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U2 - 10.1007/s00702-010-0461-0

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AN - SCOPUS:78651260221

SN - 0300-9564

VL - 117

SP - 1265

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JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 11

ER -

Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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