Central and peripheral effects of ghrelin on energy balance, food intake and lipid metabolism in teleost fish

Ki Sung Kang, Satowa Yahashi, Kouhei Matsuda*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Ghrelin was first identified and characterized from rat stomach as an endogenous ligand for the growth hormone secretagogue receptor. Ghrelin and its receptor system are present not only in peripheral tissues such as stomach and intestine, but also in the central nervous system of mammals. Interestingly, administration of ghrelin induces an orexigenic effect and also modifies locomotor activity, suggesting its involvement in feeding control and the regulation of energy balance, in addition to the regulation of growth hormone release. Information about ghrelin in non-mammals, such as teleost fish, has also been increasing, and important data have been obtained. An understanding of the evolutionary background of the energy regulation system and the central and peripheral roles of ghrelin in teleost fish could provide indications as to their roles in mammals, particularly humans. In this review, we overview the central and peripheral effects of ghrelin on energy balance, locomotor activity, and lipid metabolism in teleost fish.

Original languageEnglish
Pages (from-to)2242-2247
Number of pages6
JournalPeptides
Volume32
Issue number11
DOIs
StatePublished - 2011/11

Keywords

  • Energy balance
  • Feeding regulation
  • Ghrelin
  • Goldfish
  • Locomotor activity
  • Teleost fish

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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