CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report

Naoki Takahashi; Kazuto Tajiri; Ko Kagoyana; Shinichi Tanaka; Ichiro Yasuda

doi:10.3389/fonc.2021.672660

CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report

Naoki Takahashi, Kazuto Tajiri^*, Ko Kagoyana, Shinichi Tanaka, Ichiro Yasuda

^*Corresponding author for this work

Internal Medicine （3）

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI. Five years earlier, he had undergone curative enucleation of his left eye for uveal melanoma. US-guided biopsy revealed that the liver nodules were metastases of melanoma. Pathological examination also showed infiltration of CD8 positive T lymphocytes. The metastatic nodules remained unchanged for more than 2 years and he was not further treated. This pathology and clinical course suggest that the systemic immune response of the host could suppress hepatic metastases of uveal melanoma.

Original language	English
Article number	672660
Journal	Frontiers in Oncology
Volume	11
DOIs	https://doi.org/10.3389/fonc.2021.672660
State	Published - 2021/06/02

Keywords

CD8 positive T lymphocyte
host immune response
liver metastasis
malignant melanoma
uveal melanoma

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2021.672660

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title = "CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report",

abstract = "A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI. Five years earlier, he had undergone curative enucleation of his left eye for uveal melanoma. US-guided biopsy revealed that the liver nodules were metastases of melanoma. Pathological examination also showed infiltration of CD8 positive T lymphocytes. The metastatic nodules remained unchanged for more than 2 years and he was not further treated. This pathology and clinical course suggest that the systemic immune response of the host could suppress hepatic metastases of uveal melanoma.",

keywords = "CD8 positive T lymphocyte, host immune response, liver metastasis, malignant melanoma, uveal melanoma",

author = "Naoki Takahashi and Kazuto Tajiri and Ko Kagoyana and Shinichi Tanaka and Ichiro Yasuda",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Takahashi, Tajiri, Kagoyana, Tanaka and Yasuda.",

year = "2021",

month = jun,

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doi = "10.3389/fonc.2021.672660",

language = "英語",

volume = "11",

journal = "Frontiers in Oncology",

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TY - JOUR

T1 - CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma

T2 - A Case Report

AU - Takahashi, Naoki

AU - Tajiri, Kazuto

AU - Kagoyana, Ko

AU - Tanaka, Shinichi

AU - Yasuda, Ichiro

PY - 2021/6/2

Y1 - 2021/6/2

N2 - A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI. Five years earlier, he had undergone curative enucleation of his left eye for uveal melanoma. US-guided biopsy revealed that the liver nodules were metastases of melanoma. Pathological examination also showed infiltration of CD8 positive T lymphocytes. The metastatic nodules remained unchanged for more than 2 years and he was not further treated. This pathology and clinical course suggest that the systemic immune response of the host could suppress hepatic metastases of uveal melanoma.

AB - A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI. Five years earlier, he had undergone curative enucleation of his left eye for uveal melanoma. US-guided biopsy revealed that the liver nodules were metastases of melanoma. Pathological examination also showed infiltration of CD8 positive T lymphocytes. The metastatic nodules remained unchanged for more than 2 years and he was not further treated. This pathology and clinical course suggest that the systemic immune response of the host could suppress hepatic metastases of uveal melanoma.

KW - CD8 positive T lymphocyte

KW - host immune response

KW - liver metastasis

KW - malignant melanoma

KW - uveal melanoma

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U2 - 10.3389/fonc.2021.672660

DO - 10.3389/fonc.2021.672660

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AN - SCOPUS:85108150860

SN - 2234-943X

VL - 11

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 672660

ER -

CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report

Abstract

Keywords

ASJC Scopus subject areas

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