Cancer stem cells: The 'heartbeat' of gastric cancer

Guihua Xu; Jie Shen; Xiaohui Ou Yang; Masakiyo Sasahara; Xiulan Su

doi:10.1007/s00535-012-0712-y

Cancer stem cells: The 'heartbeat' of gastric cancer

Guihua Xu, Jie Shen, Xiaohui Ou Yang, Masakiyo Sasahara, Xiulan Su^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.

Original language	English
Pages (from-to)	781-797
Number of pages	17
Journal	Journal of Gastroenterology
Volume	48
Issue number	7
DOIs	https://doi.org/10.1007/s00535-012-0712-y
State	Published - 2013/07

Keywords

Biomarker
Cancer stem cell
Gastric cancer
Microenvironment
Signaling pathway

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00535-012-0712-y

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title = "Cancer stem cells: The 'heartbeat' of gastric cancer",

abstract = "Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.",

keywords = "Biomarker, Cancer stem cell, Gastric cancer, Microenvironment, Signaling pathway",

author = "Guihua Xu and Jie Shen and {Ou Yang}, Xiaohui and Masakiyo Sasahara and Xiulan Su",

note = "Funding Information: This study was supported by the National Natural Science Foundation of China (No. 81160254, China). ",

year = "2013",

month = jul,

doi = "10.1007/s00535-012-0712-y",

language = "英語",

volume = "48",

pages = "781--797",

journal = "Journal of Gastroenterology",

issn = "0944-1174",

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TY - JOUR

T1 - Cancer stem cells

T2 - The 'heartbeat' of gastric cancer

AU - Xu, Guihua

AU - Shen, Jie

AU - Ou Yang, Xiaohui

AU - Sasahara, Masakiyo

AU - Su, Xiulan

N1 - Funding Information: This study was supported by the National Natural Science Foundation of China (No. 81160254, China).

PY - 2013/7

Y1 - 2013/7

N2 - Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.

AB - Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.

KW - Biomarker

KW - Cancer stem cell

KW - Gastric cancer

KW - Microenvironment

KW - Signaling pathway

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U2 - 10.1007/s00535-012-0712-y

DO - 10.1007/s00535-012-0712-y

M3 - 総説

C2 - 23184096

AN - SCOPUS:84880802301

SN - 0944-1174

VL - 48

SP - 781

EP - 797

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

IS - 7

ER -

Cancer stem cells: The 'heartbeat' of gastric cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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