Calcifying pseudoneoplasm of the neuraxis (CAPNON) associated with neurenteric cyst. An autopsy case showing unusual fatal outcome

Shojiro Ichimata, Yukiko Hata, Akane Aikawa, Shin Ishizawa, Daisuke Sato, Takuya Akai, Naoki Nishida*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A 53-year-old man with a history of an untreated brain mass was taken to Toyama Prefectural Central Hospital by emergency transport. Computed tomography revealed an intracranial hypo-attenuated lesion exhibiting mass effect. Several calcified foci were observed around the lesion. His radiographical diagnosis was meningioma with calcification and edema. He suddenly showed tonic seizure after admission; therefore an emergency craniotomy was performed. However, he unfortunately died due to advanced cerebral edema. Microscopic findings of the surgically obtained materials were consistent with neurenteric cyst (NC). Intracranial hard masses were found adjacent to NCs, and the masses were composed of fibrous cartilage-like matrix with extensive linear calcification and the presence of surrounding round-to-oval epithelioid cells. Thus, calcifying pseudoneoplasm of the neuraxis (CAPNON) associated with NC was considered the most appropriate diagnosis of the present case. To the best of our knowledge, this is the first report of such a case. The present case suggests that delay of treatment might cause a poor outcome, at least in CAPNON associated with NC. Careful investigations, including the underlying pathology, may be essential when considering the etiology of CAPNON and its treatment strategies.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalNeuropathology
Volume42
Issue number6
DOIs
StatePublished - 2022/12

Keywords

  • autopsy
  • calcifying pseudoneoplasm of the neuraxis
  • immunohistochemistry
  • neurenteric cyst
  • pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

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