Brain SPECT of Creutzfeldt-Jakob disease

Naoto Watanabe*, Hikaru Seto, Masashi Shimizu, Yasuyuki Tanii, Young Do Kim, Ryoko Shibata, Makoto Kawaguchi, Shiro Tsuji, Makoto Morijiri, Masanari Kageyama, Yi Wei Wu, Masao Kakishita, Masayoshi Kurachi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

SPECT imaging with I-123 IMP or Tc-99m HMPAO was performed in two patients with Creutzfeldt-Jakob disease to evaluate abnormalities in brain perfusion. In the first patient, there was decreased perfusion of the left frontal, parietal, and temporal lobes. CT and MRI were negative. In the second patient, there was patchy perfusion and slightly decreased perfusion of the right hemisphere. MRI revealed slight brain atrophy and bilateral high intensity areas in the basal ganglia on T2 weighted images. Subsequent SPECT imaging revealed severely decreased perfusion of the entire brain. Subsequent MRI demonstrated severe brain atrophy.

Original languageEnglish
Pages (from-to)236-241
Number of pages6
JournalClinical Nuclear Medicine
Volume21
Issue number3
DOIs
StatePublished - 1996/03

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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