TY - JOUR
T1 - Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation
AU - Watanabe, Yasuharu
AU - Nagai, Yoshinori
AU - Honda, Hiroe
AU - Okamoto, Naoki
AU - Yanagibashi, Tsutomu
AU - Ogasawara, Masaru
AU - Yamamoto, Seiji
AU - Imamura, Ryu
AU - Takasaki, Ichiro
AU - Hara, Hiromitsu
AU - Sasahara, Masakiyo
AU - Arita, Makoto
AU - Hida, Shigeaki
AU - Taniguchi, Shun'ichiro
AU - Suda, Takashi
AU - Takatsu, Kiyoshi
N1 - Publisher Copyright:
© FASEB
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Chronic activation of the IL-1β system in adipose tissue on metabolic disorders is well demonstrated. However, a mechanism for its expression and activation in the tissue has remained unexplored. Here, we demonstrate that IL-1β transcript was enriched in neutrophils of white adipose tissue (WAT) from lean mice. Mechanistically, the interaction of neutrophils with adipocytes induced IL-1β expression via NF-κB pathway. Lipolysis of adipocytes accumulated neutrophils prior to macrophages in WAT and produced high levels of IL-1β via an inflammasome pathway. Leukotriene B4 (LTB4) production in WAT also contributed to neutrophil accumulation. Furthermore, an LTB4-inflammasome axis contributed to the expression of chemotactic molecules involved in high-fat diet-induced macrophage infiltration into WAT. We have identified previously unappreciated roles for neutrophils in the development of adipose tissue inflammation: robust IL-1β production and infiltration of macrophages to initiate chronic inflammation.—Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yanagibashi, T., Ogasawara, M., Yamamoto, S., Imamura, R., Takasaki, I., Hara, H., Sasahara, M., Arita, M., Hida, S., Taniguchi, S., Suda, T., Takatsu, K. Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation. FASEB J. 33, 11821-11835 (2019). www.fasebj.org.
AB - Chronic activation of the IL-1β system in adipose tissue on metabolic disorders is well demonstrated. However, a mechanism for its expression and activation in the tissue has remained unexplored. Here, we demonstrate that IL-1β transcript was enriched in neutrophils of white adipose tissue (WAT) from lean mice. Mechanistically, the interaction of neutrophils with adipocytes induced IL-1β expression via NF-κB pathway. Lipolysis of adipocytes accumulated neutrophils prior to macrophages in WAT and produced high levels of IL-1β via an inflammasome pathway. Leukotriene B4 (LTB4) production in WAT also contributed to neutrophil accumulation. Furthermore, an LTB4-inflammasome axis contributed to the expression of chemotactic molecules involved in high-fat diet-induced macrophage infiltration into WAT. We have identified previously unappreciated roles for neutrophils in the development of adipose tissue inflammation: robust IL-1β production and infiltration of macrophages to initiate chronic inflammation.—Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yanagibashi, T., Ogasawara, M., Yamamoto, S., Imamura, R., Takasaki, I., Hara, H., Sasahara, M., Arita, M., Hida, S., Taniguchi, S., Suda, T., Takatsu, K. Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation. FASEB J. 33, 11821-11835 (2019). www.fasebj.org.
KW - IL-1β inflammasome
KW - fatty acid
KW - metabolic disorder
UR - http://www.scopus.com/inward/record.url?scp=85074380001&partnerID=8YFLogxK
U2 - 10.1096/fj.201900477RR
DO - 10.1096/fj.201900477RR
M3 - 学術論文
C2 - 31355683
AN - SCOPUS:85074380001
SN - 0892-6638
VL - 33
SP - 11821
EP - 11835
JO - FASEB Journal
JF - FASEB Journal
IS - 11
ER -