Asymmetric synthesis of fagomine

Hajime Yokoyama; Hiromi Ejiri; Masahiro Miyazawa; Seiji Yamaguchi; Yoshiro Hirai

doi:10.1016/j.tetasy.2007.03.022

Asymmetric synthesis of fagomine

Hajime Yokoyama, Hiromi Ejiri, Masahiro Miyazawa, Seiji Yamaguchi, Yoshiro Hirai^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

We report an asymmetric synthesis of the alkaloid fagomine, which is an inhibitor of mammalian α-glucosidase and β-galactosidase, by means of Sharpless asymmetric dihydroxylation and Pd(II)-catalyzed cyclization, starting from 3-(t-butoxylcarbonylamino)propanol.

Original language	English
Pages (from-to)	852-856
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/j.tetasy.2007.03.022
State	Published - 2007/04/30

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery
Catalysis

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title = "Asymmetric synthesis of fagomine",

abstract = "We report an asymmetric synthesis of the alkaloid fagomine, which is an inhibitor of mammalian α-glucosidase and β-galactosidase, by means of Sharpless asymmetric dihydroxylation and Pd(II)-catalyzed cyclization, starting from 3-(t-butoxylcarbonylamino)propanol.",

author = "Hajime Yokoyama and Hiromi Ejiri and Masahiro Miyazawa and Seiji Yamaguchi and Yoshiro Hirai",

note = "Funding Information: This work was supported by a grant-in-Aid for Scientific Research in priority areas (17035032) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT).",

year = "2007",

month = apr,

day = "30",

doi = "10.1016/j.tetasy.2007.03.022",

language = "英語",

volume = "18",

pages = "852--856",

journal = "Tetrahedron Asymmetry",

issn = "0957-4166",

publisher = "Elsevier Ltd.",

number = "7",

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TY - JOUR

T1 - Asymmetric synthesis of fagomine

AU - Yokoyama, Hajime

AU - Ejiri, Hiromi

AU - Miyazawa, Masahiro

AU - Yamaguchi, Seiji

AU - Hirai, Yoshiro

N1 - Funding Information: This work was supported by a grant-in-Aid for Scientific Research in priority areas (17035032) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT).

PY - 2007/4/30

Y1 - 2007/4/30

N2 - We report an asymmetric synthesis of the alkaloid fagomine, which is an inhibitor of mammalian α-glucosidase and β-galactosidase, by means of Sharpless asymmetric dihydroxylation and Pd(II)-catalyzed cyclization, starting from 3-(t-butoxylcarbonylamino)propanol.

AB - We report an asymmetric synthesis of the alkaloid fagomine, which is an inhibitor of mammalian α-glucosidase and β-galactosidase, by means of Sharpless asymmetric dihydroxylation and Pd(II)-catalyzed cyclization, starting from 3-(t-butoxylcarbonylamino)propanol.

UR - http://www.scopus.com/inward/record.url?scp=34247601597&partnerID=8YFLogxK

U2 - 10.1016/j.tetasy.2007.03.022

DO - 10.1016/j.tetasy.2007.03.022

M3 - 学術論文

AN - SCOPUS:34247601597

SN - 0957-4166

VL - 18

SP - 852

EP - 856

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 7

ER -

Asymmetric synthesis of fagomine

Abstract

ASJC Scopus subject areas

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